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The Blood-Brain Barrier in Alzheimer's Disease

Published online by Cambridge University Press:  18 September 2015

Harry V. Vinters  and
William M. Pardridge
Harry V. Vinters*
Affiliation:
Department of Pathology, University of California, Los Angeles Brain Research Institute, University of California, Los Angeles
William M. Pardridge
Affiliation:
Department of Medicine (Endocrinology), University of California, Los Angeles Brain Research Institute, University of California, Los Angeles
*
Dept. of Pathology (Neuropathology), UCLA Medical Center, CHS 18-170, Los Angeles, CA USA 90024
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Abstract:

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The current evidence for and against abnormalities of the blood-brain barrier in “normal” aging and Alzheimer's disease is reviewed. Recent studies of cerebral amyloid angiopathy, a microangiopathy commonly observed in Alzheimer's disease and one suggested to result from blood-brain barrier derangement, are discussed with particular attention to the biochemical nature of the vascular amyloid material, and features it shares with the amyloid found in senile plaque cores and with neurofibrillary tangles. Modern techniques that will probably clarify blood-brain barrier pathophysiology are reviewed.

Type
Cellular Clues to Pathogenesis
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue S4 , November 1986 , pp. 446 - 448
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

References

1.Reese, TS, Karnovsky, MJ.Fine structural localization of a blood-brain barrier to exogenous peroxidase. J Cell Biol 1967; 34: 207–217.CrossRefGoogle ScholarPubMed
2.Bradbury, MWB.The structure and function of the blood-brain barrier. Fed Proc 1984; 43: 186–190.Google ScholarPubMed
3.Conford, EM.The blood-brain barrier, a dynamic regulatory interface. Molec Physiol 1985; 7: 219–260.Google Scholar
4.Petito, CK, Levy, DE.The importance of cerebral arterioles in alterations of the blood-brain barrier. Lab Invest 1980; 43: 262–268.Google ScholarPubMed
5.Pardridge, WM.Transport of nutrients and hormones through the blood-brain barrier. Fed Proc 1984; 43: 201–204.Google ScholarPubMed
6.Pardridge, WM.Brain metabolism: a perspective from the blood-brain barrier. Physiol Rev 1983; 63: 1481–1535.CrossRefGoogle ScholarPubMed
7.Glenner, GG.Congophilic microangiopathy in the pathogenesis of Alzheimer’s syndrome (presenile dementia). Med Hypotheses 1979; 5: 1231–1236.CrossRefGoogle ScholarPubMed
8.Glenner, GG.On causative theories in Alzheimer’s disease. Hum Pathol 1985; 16: 433–435.CrossRefGoogle ScholarPubMed
9.Rudick, RA, Buell, SJ.Integrity of blood-brain barrier to peroxidase in senescent mice. Neurobiol Aging 1983; 4: 283–287.CrossRefGoogle ScholarPubMed
10.Rapoport, SI, Ohno, K, Pettigrew, KD.Blood-brain barrier perme-ability in senescent rats. J Gerontol 1979; 34: 162–169.CrossRefGoogle Scholar
11.Stewart, PA, Magliocco, M, Hayakawa, K, et al. A quantitative analysis of blood-brain barrier ultrastructure in the aging human. Microvasc Res 1986; (in press).Google Scholar
12.Creasey, H, Rapoport, SI.The aging human brain. Ann Neurol 1985; 17: 2–10.CrossRefGoogle ScholarPubMed
13.Wisniewski, HM, Kozlowski, PB.Evidence for blood-brain barrier changes in senile dementia of the Alzheimer type (SDAT). Ann NY Acad Sci 1982; 396: 119–129.CrossRefGoogle ScholarPubMed
14.Leonardi, A, Gandolfo, C, Caponnetto, C, et al. The integrity of the blood-brain barrier in Alzheimer’s type and multi-infarct dementia evaluated by the study of albumin and IgG in serum and cerebrospinal fluid. J Neurol Sci 1985; 67: 253–261.CrossRefGoogle Scholar
15.Raichle, ME, Hartman, BK, Eichling, JO, et al. Central noradrenergic regulation of cerebral blood flow and vascular permeability Proc Natl Acad Sci USA 1975; 72: 3726–3730.CrossRefGoogle ScholarPubMed
16.Harik, SI, McGunigal, T Jr.The protective influence of the locus ceruleus on the blood-brain barrier. Ann Neurol 1984; 15: 568–574.CrossRefGoogle ScholarPubMed
17.Lockhart, MP, Gibson, CJ, Ball, MJ.Topographical loss of locus coeruleus cells in Alzheimer’s disease. Neuroscience Abstracts 1984; 10: 995.Google Scholar
18.Tomlinson, BE, Irving, D, Blessed, G.Cell loss in the locus coeruleus in senile dementia of Alzheimer type. J Neurol Sci 1981; 49: 419–428.CrossRefGoogle ScholarPubMed
19.Bondareff, W, Mountjoy, CQ, Roth, M.Loss of neurons of origin of the adrenergic projection to cerebral cortex (nucleus locus ceruleus) in senile dementia. Neurology 1982; 32: 164–168.CrossRefGoogle ScholarPubMed
20.Vinters, HV.Cerebral amyloid angiopathy — a critical review. Stroke 1986; (in press).Google Scholar
21.Richardson, EP Jr.Amyloid in the human brain. West J Med 1985; 143: 518–519.Google ScholarPubMed
22.Torack, RM, Lynch, RG.Cytochemistry of brain amyloid in adult dementia. Acta Neuropathol (Berl) 1981; 53: 189–196.CrossRefGoogle ScholarPubMed
23.Probst, A, Heitz, PhU, Ulrich, J.Histochemical analysis of senile plaque amyloid and amyloid angiopathy. Virchows Arch [A] 1980; 388: 327–334.CrossRefGoogle ScholarPubMed
24.Eikelenboom, P, Stam, FC.An immunohistochemical study on cerebral vascular and senile plaque amyloid in Alzheimer’s dementia. Virchows Arch [Cell Pathol] 1984; 47: 17–25.CrossRefGoogle Scholar
25.Powers, JM, Schlaepfer, WW, Willingham, MC, et al. An immuno-peroxidase study of senile cerebral amyloidosis with pathogenetic considerations. J Neuropathol Exp Neurol 1981; 40: 592–612.CrossRefGoogle Scholar
26.Goust, J-M, Mangum, M, Powers, JM.An immunologic assessment of brain-associated IgG in senile cerebral amyloidosis. J Neuropathol Exp Neurol 1984; 43: 481–488.CrossRefGoogle Scholar
27.Vinters, HV, Gilbert, JJ.Cerebral amyloid angiopathy: incidence and complications in the aging brain. II. The distribution of amyloid vascular changes. Stroke 1983; 14: 924–928.CrossRefGoogle ScholarPubMed
28.Tomonaga, M.Cerebral amyloid angiopathy in the elderly. J Am Geriatr Soc 1981; 29: 151–157.CrossRefGoogle ScholarPubMed
29.Gilbert, JJ, Vinters, HV.Cerebral amyloid angiopathy: incidence and complications in the aging brain. I. Cerebral hemorrhage. Stroke 1983; 14: 915–923.CrossRefGoogle ScholarPubMed
30.Okazaki, H, Reagan, TJ, Campbell, RJ.Clinicopathologic studies of primary cerebral amyloid angiopathy. Mayo Clin Proc 1979; 54: 22–31.Google ScholarPubMed
31.Gilles, C, Brucher, JM, Khoubesserian, P, et al. Cerebral amyloid angiopathy as a cause of multiple intracerebral hemorrhages. Neurology 1984; 34: 730–735.CrossRefGoogle ScholarPubMed
32.Glenner, GG, Henry, JH, Fujihara, S.Congophilic angiopathy in the pathogenesis of Alzheimer’s degeneration. Ann Pathol 1981; 1: 120–129.Google ScholarPubMed
33.Mlandybur, Tl.The incidence of cerebral amyloid angiopathy in Alzheimer’s disease. Neurology 1975; 25: 120–126.CrossRefGoogle Scholar
34.Ranalli, P, Bergeron, C.Amyloid angiopathy in Alzheimer’s disease. Ann Neurol 1984; 16: 119.Google Scholar
35.Ball, MJ, Hachinski, V, Fox, A, et al. A new definition of Alzheimer’s disease: a hippocampal dementia. Lancet 1985; 1: 14–16.CrossRefGoogle ScholarPubMed
36.Morimatsu, M, Hirai, S, Muramatsu, A, et al. Senile degenerative brain lesions and dementia. J Am Geriatr Soc 1975; 23: 390–406.CrossRefGoogle ScholarPubMed
37.Mountjoy, CQ, Tomlinson, BE, Gibson, PH.Amyloid and senile plaques and cerebral blood vessels. A semi-quantitative investigation of a possible relationship. J Neurol Sci 1982; 57: 89–103.CrossRefGoogle ScholarPubMed
38.Glenner, GG, Wong, CW.Alzheimer’s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Comm 1984; 120: 885–890.CrossRefGoogle ScholarPubMed
39.Idem, A. eimer’s disease and Down’s syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem Biophys Res Comm 1984; 122: 1131–1135.Google Scholar
40.Wong, CW, Quaranta, V, Glenner, GG.Neuritic plaques and cerebro-vascular amyloid in Alzheimer disease are antigenically related. Proc Natl Acad Sci USA 1985; 82: 8729–8732.CrossRefGoogle Scholar
41.Pardridge, WM, Vinters, HV, Yang, J, et al. Amyloid angiopathy of Alzheimer’s disease: amino acid composition of a 4200 dalton peptide isolated from cortical microvessels. 1986, (submitted).Google Scholar
42.Masters, CL, Simms, G, Weinman, NA, et al. Amyloid plaque core protein in Alzheimer’s disease and Down syndrome. Proc Natl Acad Sci USA 1985; 82: 4245–4249.CrossRefGoogle ScholarPubMed
43.Allsop, D, Landon, M, Kidd, M.The isolation and amino acid composition of senile plaque core protein. Brain Res 1983; 259: 348–352.CrossRefGoogle ScholarPubMed
44.Masters, CL, Multhaup, G, Simms, G, et al. Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer’s disease contain the same protein as the amyloid of plaque cores and blood vessels. EMBO J 1985; 4: 2757–2763.CrossRefGoogle ScholarPubMed
45.Glenner, GG.Alzheimer’s disease. The commonest form of amyloidosis. Arch Pathol Lab Med 1983; 107: 281–282.Google ScholarPubMed
46.Glenner, GG.Alzheimer’s disease: multiple cerebral amyloidosis. In: Banbury Report 15: Biological aspects of Alzheimer’s disease. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory, 1983: 137–144.Google Scholar
47.Pardridge, WM, Eisenberg, J, Yang, J.Human blood-brain barrier insulin receptor. J Neurochem 1985; 44: 1771–1778.CrossRefGoogle ScholarPubMed
48.Choi, T, Pardridge, WM.Phenylalanine transport at the human blood-brain barrier. Studies with isolated human brain capillaries. J Biol Chem 1986; 261: 6536–6541.CrossRefGoogle ScholarPubMed
49.Joó, F.The blood-brain barrier in vitro: ten years of research on microvessels isolated from the brain. Neurochem Int. 1985; 7: 1–25.CrossRefGoogle ScholarPubMed
50.Vinters, HV, Reave, S, Costello, P, et al. Isolation and culture of cells derived from human cerebral microvessels. J Neuropathol Exp Neurol 1985; 44: 338.CrossRefGoogle Scholar
51.Beck, DW, Vinters, HV, Hart, MN, Cancilla, PA.Glial cells influence polarity of the blood-brain barrier. J Neuropathol Exp Neurol 1984; 43: 219–224.CrossRefGoogle ScholarPubMed
52.Bowman, PD, Ennis, SR, Rarey, KE, et al. Brain microvessel endothelial cells in tissue culture: a model for study of blood-brain barrier permeability. Ann Neurol 1983; 14: 396–402.CrossRefGoogle Scholar