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Botulinum Toxin for Benign Essential Blepharospasm, Hemifacial Spasm and Age-Related Lower Eyelid Entropion

Published online by Cambridge University Press:  18 September 2015

Jean Carruthers  and
Harrison A. Stubbs
Jean Carruthers*
Affiliation:
Department of Ophthalmology, University of British Columbia, Vancouver
Harrison A. Stubbs
Affiliation:
Department of Biomedical and Environmental Health Science, School of Public Health, University of California, Berkeley
*
Suite 210, 2730 Commercial Drive, Vancouver, B.C., Canada V5N 5P4
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Abstract:

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Purified botulinum A exotoxin was used in the treatment of forty seven patients with benign essential blepharospasm, 11 patients with hemifacial spasm and 2 patients with age-related entropion. The treatment was effective in all three groups for an average of 3-4 months when symptoms recurred and repeated chemodenervation with toxin was needed. The commonest complication was transient ptosis with an overall frequency of 7.8%. This incidence increased to 11.1% with toxin doses higher than 25 units per orbicularis. The treatment was well accepted by the patients, who were subsequently able to return to pre-blepharospasm lifestyles.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 14 , Issue 1 , February 1987 , pp. 42 - 45
Copyright
Copyright © Canadian Neurological Sciences Federation 1987

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