Hostname: page-component-cd9895bd7-hc48f Total loading time: 0 Render date: 2024-12-28T01:57:45.040Z Has data issue: false hasContentIssue false
  • English
  • Français

Case Report and Ultrastructural Study of Intracranial Embryonal Carcinoma

Published online by Cambridge University Press:  18 September 2015

Gerson Ejeckam ,
Margaret G. Norman  and
Leslie P. Ivan
Gerson Ejeckam
Affiliation:
Division of Pathology, Eleanor M., Paterson Laboratory and Division of Neurosurgery, Children's Hospital of Eastern Ontario, Ottawa and the Departments of Pathology and Surgery, University of Ottawa
Margaret G. Norman*
Affiliation:
Division of Pathology, Eleanor M., Paterson Laboratory and Division of Neurosurgery, Children's Hospital of Eastern Ontario, Ottawa and the Departments of Pathology and Surgery, University of Ottawa
Leslie P. Ivan
Affiliation:
Division of Pathology, Eleanor M., Paterson Laboratory and Division of Neurosurgery, Children's Hospital of Eastern Ontario, Ottawa and the Departments of Pathology and Surgery, University of Ottawa
*
Dept. Pathology, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada.
Rights & Permissions [Opens in a new window]

Summary:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A case of a primary intracranial embryonal carcinoma, the first with ultrastructural study, is reported. The tumor was associated with precocious puberty in a 6½-year-old female. Characteristic embryoid bodies were present. At the ultrastructural level three cell types were noted: undifferentiated, differentiated, and intermediate types. The undifferentiated showed scanty cytoplasmic organelles and numerous free polysomes, while the differentiated cells contained well-developed mitochondria, Golgi apparatus, rough endoplasmic reticulum, and some contained secretory granules. The intermediate cells possessed dilated and irregularly-shaped mitochondria but still retained large numbers of free polysomes. The authors suggest that intracranial germ cell tumors be named in conformity with germ cell tumors in other sites, and that terms such as “ectopic pinealoma” and “atypical teratoma of the pineal” be used no longer.

Type
Case Report
Information
Canadian Journal of Neurological Sciences , Volume 5 , Issue 4 , November 1978 , pp. 447 - 450
Copyright
Copyright © Canadian Neurological Sciences Federation 1978

References

REFERENCES

Albrechtsen, R., Klee, J.G. and Miller, J.E. (1972). Primary intracranial germ cell tumors including five cases of endodermal sinus tumor. Acta Path Microbiol Scand, Section A 80 Suppl. 233,32.Google Scholar
Allyn, D.C., Silverberg, S.G., Salzberg, A.M. (1971). Endodermal sinus tumor of vagina. Report of a case with 7 year survival and literature review of so called “mesonephromas”. Cancer, 27, 1231–1238.3.0.CO;2-L>CrossRefGoogle ScholarPubMed
Ballas, A.S.M. (1972). Yolk sac carcinoma of ovary with alphafetoprotein in the serum and ascitic fluid demonstrated by immuno-osmorphoresis. Am J Clin Pathol, 57, 511–516.CrossRefGoogle Scholar
Borit, A. (1969). Embryonal carcinoma of the pineal region. J Pathol, 97, 165–168.CrossRefGoogle ScholarPubMed
Collins, D.H., Pugh, R.C.B. (1964). The pathology of testicular tumors. BrJ Urol, 36, supp. 1–11.Google Scholar
Dayan, A.D., Marshall, A.H.E., Miller, A.A., Pick, F.J. and Rankin, N.E. (1966). A typical teratoma of the pineal and hypothalamus. J Path Bact, 92, 1–28.CrossRefGoogle Scholar
Dixon, F.J. Jr., Moore, R.A. (1953). Testicular tumors. A clinicopathologic study. Cancer, 6, 427–454.3.0.CO;2-U>CrossRefGoogle Scholar
El-Domeiri, A.A., Hunter, R.V., Pool, J.L. (1968). Primary seminoma of the anterior mediastinum. Ann Thoracic Surg, 6, 513–521.CrossRefGoogle ScholarPubMed
Friedman, N.B. (1951). The comparative morphogenesis of extra genital and gonadal teratoid tumors. Cancer, 4, 265–276.3.0.CO;2-X>CrossRefGoogle Scholar
Ishiguro, T. (1975). Serum alpha fetoprotein in hydatidiform mole, chario-carcinoma and twin pregnancy. Am J Obstet Gynecol, 121, 539–541.CrossRefGoogle ScholarPubMed
Jellinger, K., Minauf, M., Kraus, H. and Sunder-Plassman, M. (1970). Embryonales Carcinom der Epiphysenre-gon. Acta Neuropathol (Berl), 15, 176–182.CrossRefGoogle Scholar
Kleinsmith, L.J., Pierce, G.B. Jr. (1964). Multipotentiality of single embryonal carcinoma cells. Cancer Res, 24, 1544–1551.Google ScholarPubMed
Kurman, R.J. and Norris, H.J. (1976). Embryonal carcinoma of the ovary. A clinical and pathologic entity distinct from endodermal sinus tumor resembling embryonal carcinoma of adult testis. Cancer, 38, 2420–2433.3.0.CO;2-2>CrossRefGoogle ScholarPubMed
Kurman, R.J. and Norris, H.J. (1977). Malignant germ cell tumors of the ovary. Human Pathol, 8, 555–564.CrossRefGoogle ScholarPubMed
Løken, A.C. (1957). On the relation of a typical pinealomas to teratoid tumors. Acta path microbiol scand, 40, 417–424.Google Scholar
Pierce, G.B. Jr. (1966). Ultrastructure of human testicular tumor. Cancer, 19, 1963–1983.3.0.CO;2-G>CrossRefGoogle Scholar
Pierce, G.B. Jr. and Beals, T.F. (1964). The ultrastructure of primordial germinal cells of the fetal testes and embryonal carcinoma of cells in mice. Cancer Res, 24, 1553–1567.Google Scholar
Russell, D.S. and Rubinstein, L.J. (1977). Pathology of tumors of the nervous system. Edinburgh, Edward Arnold Publishers Ltd. ed. 4, pp. 285–290.Google Scholar
Talerman, A. and Haije, W.G. (1974). Alpha fetoprotein and germ cell tumors: a possible role of yolk sactumor in production of alpha fetoprotein. Cancer, 34, 1722–1726.3.0.CO;2-F>CrossRefGoogle Scholar
Teilum, G. (1965). Classification of endodermal sinus tumor (mesoblastoma vitellinum) and so called embryonal carcinoma of the ovary. Acta Pathol Microbiol Scand, 64, 407–429.CrossRefGoogle Scholar
Thiele, J., Castro, S., Lee, K.D. (1971). Extragonadal endodermal sinus tumor (yolk sac tumor) of the pelvis. Cancer, 27, 391–396.3.0.CO;2-H>CrossRefGoogle ScholarPubMed