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Cataleptic Effect of 61-91 Beta-Lipotropic Hormone in Rat

Published online by Cambridge University Press:  03 July 2018

T. Motomatsu ,
M. Lis. N. Seidah  and
M. Chrétien
T. Motomatsu
Affiliation:
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec
M. Lis. N. Seidah
Affiliation:
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec
M. Chrétien*
Affiliation:
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec
*
Clinical Research Institute of Montreal, 110 Pine Avenue, West, Montréal H2W 1R7, Canada.
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Summary

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Intraventricular administration of a peptide from ovine pituitaries whose structure is identical to the 61-91 C-terminal portion of beta-lipotropic hormone (61-91 beta-LPH) induced catalepsy, muscular hypertonus and analgesia in rats. Naloxone inhibited both the analgesic and cataleptic effects. l-dihydroxyphenylalanine (l-DOPA) completely prevented the cataleptic effect. The cataleptic effect of 61-91 beta-LPH was potentiated by 1-5-hydroxytryptophan (5-HTP).

Résumé

Résumé

L’administration intraventriculaire d’un peptide isolé d’hypophyses de mouton, peptide dont la structure est identique au fragment carboxy-terminal 61-91 de la béta-lipotropine produit de la catalepsie, de l’hypertonie musculaire et de l’analgésie chez le rat. La naloxone inhibe les effets analgésiques et cataleptiques. La l-dihydroxyphenylalanine (l-DOPA) a prévenu totalement l’effet cataleptique. Celui-ci était par contre potentialisé par du l-5-hydroxytryptophane (5-HTP).

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 4 , Issue 1 , February 1977 , pp. 49 - 52
Copyright
Copyright © Canadian Neurological Sciences Federation 1977

References

Banerjee, U., Burks, T. F., Feldberg, W. and Goodrich, C. A. (1968). Temperature effects and catalepsy produced by morphine injected into the cerebral ventricles of rabbits. Brit. J. Pharmacol. 33: 544–551.Google Scholar
Bradbury, A. F., Smyth, D. G. and Snell, C. R. (1976). Lipotropin: precursor to two biologically active peptides. Biochem. Biophys. Res. Comm. 69: 950–956.Google Scholar
Chretien, M., Benjannet, S., Dragon, N., Seidah, N. G. and Lis, M. Isolation of peptides with opiate activity from sheep and human pituitaries: relationship to beta-lipotropin. Biochem. Biophys. Res. Commun, (in Press).Google Scholar
Costal, B. and Naylor, R. J. (1974). A. role for the amygdala in the development of the cataleptic and stereotypic actions of the narcotic agonists and antagonists in the rat. Psychopharmacologia (Berl.) 35: 203–213.Google Scholar
Costal, B. and Naylor, R. J. (1975). Serotonergic involvement with the stereotypy/catalepsy induced by morphine-like agents in the rat. J. Pharm. Pharmac. 27: 67–69.Google Scholar
Cox, B. M., Opheim, K. E., Teschemacher, H. and Goldstein, A. (1975). A peptide-like substance from pituitary that acts like morphine. Purification and property. Life Science 16: 1777–1782.Google Scholar
Donaldson, J., St-Pierre, T., Minnich, J. and Barbeau, A. (1971). Seizures in rats associated with divalent cation inhibition of Na + -K + -ATP’ase. Can. J. Biochem. 49: 1217–1224.Google Scholar
Fog, R. (1970). Behavioral effects in rats of morphine and amphethamine and of a combination of two drugs. Psychopharmacologia (Berl.) 16: 305–312.Google Scholar
Guillemin, R., Ling, N. and Burgus, R. (1976). Endorphines, peptides, d’origine hypothalamique et neurohypophysaire à activité morphinomimeétique. Isolement et structure moléculaire de l-alpha-endorphine. C. R. Acad. Sc. Paris 282: 783–785.Google Scholar
Hughes, J., Smith, T. W., Kosterlitz, H. W., Fothergill, L. A., Morgan, B. A. and Morris, H. R. (1975). Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature 258: 577–579.CrossRefGoogle ScholarPubMed
Hughes, J. (1975). Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine. Brain Res. 88: 295–308.Google Scholar
Kostowski, W., Gumulka, W. and Czlonkowski, A. (1972). Reduced cataleptogenic effects of some neuroleptics in rats with lessioned midbrain raphe and treated with p-chlorophenylalanine. Brain Res. 48: 443–446.CrossRefGoogle Scholar
Li, C. H., and Chung, D. (1976). Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands. Proc. Nat. Acad. Sci. U.S.A. 73: 1145–1148.Google Scholar
Litchfield, J. T. and Wilcoxon, F. (1949). A simplified method of evaluating dose effect experiments. Pharmacol. Exp. Therap. 36: 99–113.Google Scholar
Pasternak, G. W., Goodman, R., and Snyder, S. H. (1975). An endogenous morphine-like factor in mammalian brain. Life Science 16: 1765–1769.Google Scholar
Pert, C. B. and Snyder, S. H. (1973). Opiate receptor: Demonstration in nervous tissue. Science 179: 1011–1014.Google Scholar
Seidah, N. G., Lis, M., Gianoulakis, C., Schiller, P. and Chretien, M. (1976). Fragment of sheep beta-lipotropin with morphine-like activity. Lancet 1:1017.Google Scholar
Seidah, N. G., Lis, M., Gianoulakis, C., Routheir, R., Benjannet, S., Schiller, P. W. and Chretien, M. Morphine-like activity of sheep betalipotropin and of its fragments. Can. J. Biochem. (in Press).Google Scholar
Simantov, R., Kuhar, M. J., Pasternak, G. W. and Snyder, S. H. (1976a). The regional distribution of a morphine-like factor enkephalin in monkey brain. Brain Res. 106: 189–197 Google Scholar
Simantov, R., Snowman, A. M. and Snyder, S. H. (1976b). A morphine-like factor enkephalin in rat brain; subcellular localization. Brain Res. 107: 650–657 CrossRefGoogle ScholarPubMed
Simantov, R. and Snyder, S. H. (1976). Isolation and structure identification of a morphine-like peptide “enkephalin” in bovine brain. Life Sci. 18: 781–788.Google Scholar
Terenius, L. and Wahlstrom, A. (1975). Morphine-like ligand for opiate receptors in human CSF Life Science 16: 1759–1764.Google Scholar
Teschemacker, H., Opheim, K. E., Cox, B. M. and Goldstein, A. (1975). A peptide-like substance from pituitary that acts like morphine. Life Science 16: 1771–1776.Google Scholar