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CD226 Gly307Ser Association With Neuromyelitis Optica in Southern Han Chinese

Published online by Cambridge University Press:  02 December 2014

Chao Liu ,
Guansan Wang ,
Hong Liu ,
Yue Li ,
Jin Li ,
Yongqiang Dai  and
Xueqiang Hu
Chao Liu
Affiliation:
Guangzhou Forensic Science Institution (Guangdong Provincial Key Laboratory of Forensic Genetic)
Guansan Wang
Affiliation:
Guangzhou Forensic Science Institution (Guangdong Provincial Key Laboratory of Forensic Genetic)
Hong Liu
Affiliation:
Guangzhou Forensic Science Institution (Guangdong Provincial Key Laboratory of Forensic Genetic)
Yue Li
Affiliation:
Guangzhou Forensic Science Institution (Guangdong Provincial Key Laboratory of Forensic Genetic)
Jin Li
Affiliation:
Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, China
Yongqiang Dai
Affiliation:
Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, China
Xueqiang Hu*
Affiliation:
Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, China
*
Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun yat-sen University, No.600 Tianhe Road, Guangzhou 510630, Guangdong Province, China. Email: huxueqiangzssy@yahoo.com.cn
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Abstract

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Background:

Neuromyelitis optica (NMO) and multiple sclerosis (MS) are autoimmune diseases of the central nervous system with complex pathogeneses. NMO was once considered to be a severe variant of MS. There has been more evidence that a non-synonymous exchange (rs763361/Gly307Ser) in the gene for CD226 is linked to several autoimmune diseases including multiple sclerosis (MS). However, no studies have investigated the role of rs763361 in the pathogenesis of NMO.

Objectives:

The goal of our study is to evaluate the role of CD226 Gly307Ser in neuromyelitis optica (NMO) in Southern Han Chinese.

Methods:

Eight-nine NMO patients, 93 relapsing-remitting multiple sclerosis (RRMS) patients, and 122 controls (CTLs) were enrolled. The rs763361 alleles of the subjects were determined by sequencing-based typing.

Results:

The results strongly support that the TT genotypes are associated with NMO but are not significantly correlated with susceptibility for MS.

Conclusions:

CD226 Gly307Ser may correlate with risk of NMO in Southern Han Chinese.

Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 39 , Issue 4 , July 2012 , pp. 488 - 490
Copyright
Copyright © The Canadian Journal of Neurological 2012

References

1.Alcina, A, Vandenbroeck, K, Otaegui, D, et al.The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis. Genes Immun. 2010;11(5):439–45.Google Scholar
2.Ross, RT, Cheang, M, Landry, G, et al.Herpes zoster and multiple sclerosis. Can J Neurol Sci. 1999;26:29–32.Google Scholar
3.Wang, H, Dai, Y, Qiu, W, et al.HLA-DPB1 0501 is associated with susceptibility to anti-aquaporin-4 antibodies positive neuromyelitis optica in southern Han Chinese. J Neuroimmunol. 2011;233(1-2):181–4.Google Scholar
4.Lennon, VA, Wingerchuk, DM, Kryzer, TJ, et al.A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis. Lancet. 2004;364:2106–12.Google Scholar
5.Zipp, F, Windemuth, C, Pankow, H, et al.Multiple sclerosis associated amino acids of polymorphic regions relevant for the HLA antigen binding are confined to HLA-DR2. Hum Immunol. 2000;61(10):1021–30.Google Scholar
6.Rodrigo, L, Hernández-Lahoz, C, Fuentes, D, et al.Prevalence of celiac disease in multiple sclerosis. BMC Neurol. 2011;7(11):31.Google Scholar
7.Svejgaard, A.The immunogenetics of multiple sclerosis. Immunogenetics. 2008;60(6):275–86.Google Scholar
8.Yamasaki, K, Horiuchi, I, Minohara, M, et al.HLA-DPB1*0501 associated optico-spinal multiple sclerosis: clinical, neuroimaging and immunogenetic studies. Brain.1999;122:1689–96.Google Scholar
9.Matsushita, T, Matsuoka, T, Isobe, N, et al.Association of the HLA-DPB1*0501 allele with antiaquaporin-4 antibody positivity in Japanese patients with idiopathic central nervous system demyelinating disorders. Tissue Antigens. 2009;73:171–6.Google Scholar
10.Lundström, W, Greiner, E, Lundmark, F, et al.No influence on disease progression of non-HLA susceptibility genes in MS. J Neuroimmunol. 2011;237(1-2):98–100.Google Scholar
11.Fang, L, Isobe, N, Yoshimura, S, et al.For the South Japan Multiple Sclerosis Genetics Consortium. Interleukin-7 receptor alpha gene polymorphism influences multiple sclerosis risk in Asians. Neurology. 2011;76(24):2125–7.Google Scholar
12.Elishmereni, M, Bachelet, I, Levi-Schaffer, F.DNAM-1: an amplifier of immune responses as a therapeutic target in various disorders. Curr Opin Investig Drugs. 2008;9(5):491–6.Google Scholar
13.Hafler, JP, Maier, LM, Cooper, JD, International Multiple Sclerosis Genetics Consortium (IMSGC), et al.CD226 Gly307Ser association with multiple autoimmune diseases. Genes Immun. 2009;10(1):5–10.Google Scholar
14.International Multiple Sclerosis Genetics Consortium (IMSGC). The expanding genetic overlap between multiple sclerosis and type I diabetes. Genes Immun. 2009;10(1):11–14.Google Scholar
15.Du, Y, Tian, L, Shen, LX, Wang, F, et al.Association of the CD226 single nucleotide polymorphism with systemic lupus erythematosus in the Chinese Han population. Tissue Antigens. 2011;77(1):65–77.Google Scholar
16.Wieczorek, S, Hoffjan, S, Chan, A, et al.Novel association of the CD226 (DNAM-1) Gly307Ser polymorphism in Wegener’s granulomatosis and confirmation for multiple sclerosis in German patients. Genes Immun. 2009;10(6):591–5.Google Scholar
17.Wingerchuk, DM.Neuromyelitis optica. Int MS J. 2006;13:42–50.Google Scholar
18.Polman, CH, Reingold, SC, Banwell, B, et al.Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011;69:292–302.Google Scholar
19.Shibuya, A, Lanier, LL, Phillips, JH. Protein kinase C is involved in the regulation of both signaling and adhesion mediated by DNAX accessory molecule-1 receptor. J Immunol. 1998;161:1671–6.Google Scholar
20.Shibuya, K, Shirakawa, J, Kameyama, T, et al.CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation. J Exp Med. 2003 Dec 15;198(12):1829–39.Google Scholar
21.Deshmukh, HA, Maiti, AK, Kim-Howard, XR, et al.Evaluation of 19 autoimmune disease-associated loci with rheumatoid arthritis in a Colombian population: evidence for replication and gene-gene interaction. J Rheumatol. 2011 Sep;38(9):1866–70.Google Scholar
22.Dieudé, P, Guedj, M, Truchetet, ME, et al.Association of the CD226 Ser(307) variant with systemic sclerosis: evidence of a contribution of costimulation pathways in systemic sclerosis pathogenesis. Arthritis Rheum. 2011 Apr;63(4):1097–105.Google Scholar