Hostname: page-component-cd9895bd7-q99xh Total loading time: 0 Render date: 2024-12-28T02:19:24.206Z Has data issue: false hasContentIssue false
  • English
  • Français

Cerebral Tissue Response to Electrode Implantation

Published online by Cambridge University Press:  18 September 2015

Ronald F. Dodson ,
L.W-F Chu  and
N. Ishihara
Ronald F. Dodson*
Affiliation:
Department of Experimental Pathology, The University of Texas Health Center at Tyler, Texas 75710. The Baylor-Methodist Center for Cerebrovascular Research and The Department of Pathology, Baylor College of Medicine, Houston, Texas 77030
L.W-F Chu
Affiliation:
Department of Experimental Pathology, The University of Texas Health Center at Tyler, Texas 75710. The Baylor-Methodist Center for Cerebrovascular Research and The Department of Pathology, Baylor College of Medicine, Houston, Texas 77030
N. Ishihara
Affiliation:
Department of Experimental Pathology, The University of Texas Health Center at Tyler, Texas 75710. The Baylor-Methodist Center for Cerebrovascular Research and The Department of Pathology, Baylor College of Medicine, Houston, Texas 77030
*
Departments of Experimental Pathology & Environmental Sciences, University of Texas Health Center, P.O. Box 2003, Tyler, Texas 75710, U.S.A.
Rights & Permissions [Opens in a new window]

Summary:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Tissue response to platinum electrodes was assessed after an eight-day implantation period. The regions of study included the cortical areas at the opercular gyri and at the sulcus parielo-occipitalis externus, as well as the sub-cortical white matter in these areas.

Perivascular and intraparenchymal hemorrhagic lesions as well as edematous changes characterized both by extensive intra and extracellular swelling were noted. Numerous phagocytic elements and degenerative structures were present at the electrode I parenchymal interface.

Tissue alterations were asymmetrical as observed both around and at the lip of the implanted electrode. The parenchymal alterations extended from 0.2mm to 3.5mm distance from the electrode path/ parenchymal interface.

Greater tissue involvement was found in the subcortical white matter as compared to the adjacent cortical gray matter.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 5 , Issue 4 , November 1978 , pp. 443 - 446
Copyright
Copyright © Canadian Neurological Sciences Federation 1978

References

REFERENCES

Aukland, K., Bower, B.F., and Berlinen, B. W. (1964). Measurement of local blood flow with hydrogen gas. Circ. Res., 14:164-187.CrossRefGoogle ScholarPubMed
Boast, C.A., Reid, S.A., Johnson, P., and Zornetzer, S.F. (1976). A caution to brain scientists: Unsuspected hemorrhagic vascular damage resulting from mere electrode implantation. Brain Research, 103:527-534.CrossRefGoogle ScholarPubMed
Collias, J.C., and Manuelidis, E.E. (1957). Histopathological changes produced by implanted electrodes in cat brains. J. Neurosurg., 14:302-328.CrossRefGoogle ScholarPubMed
Dodson, R.F., Tagashira, Y., Kawamura, Y., AND Chu, L.W-F (1975). Morphological responses of cerebral tissues to temporary ischemia. Can. J. Neurol. Sci., 2:173-177.CrossRefGoogle ScholarPubMed
Farkas-Bargeton, E., Olsson, Y., Guth, L., and Klatzo, I. (1972). Glycogen reaction to cerebral stab wound during maturation of rat brain. Acta Neuropath. (Berl.), 22:158-169.CrossRefGoogle ScholarPubMed
Herz, M.J., Marshall, K.E., and Peeke, H.V.S. (1974). Brain stimulation and behavior: Controls and consequences. Physiol. Psychol., 2:184-186.CrossRefGoogle Scholar
Meyer, J.S., Fukuuchi, Y., Kanda, T., Shimazu, K., and Hashi, K. (1972). Regional cerebral blood flow measured by intracarotid injection of hydrogen. Comparison of regional vasimotor capacitance from cerebral infarction versus compression. Neurology, 22:571-584.Google ScholarPubMed
Persson, L., and Hansson, H.A. (1976). Reversible blood-brain barrier dysfunction to peroxidase after a small stab wound in the rat cerebral cortex. Acta Neuropath (Bed.), 35:333-342.Google ScholarPubMed
Reynolds, E.S. (1963). The use of lead citrate at high pH as an electron opaque stain in electron microscopy. J. Cell Biol., 17:209-213.CrossRefGoogle ScholarPubMed
Robinson, N., Duncan, P., Gehrt, M., Sances, A., and Evans, S. (1975). Histochemistry of trauma after electrode implantation and stimulation in the hippocampus. Arch. Neurol., 32:98-102.CrossRefGoogle ScholarPubMed
Schultz, R.L., and Willey, T.J. (1976). The ultrastructure of the sheath around chronically implanted electrodes in brain. J. Neurocytol., 5:621-642.CrossRefGoogle ScholarPubMed
Spurr, A.R. (1969). A low-viscosity epoxy resin embedding medium for electron microscopy. J. Ultrastruct. Res., 26:31-43.CrossRefGoogle ScholarPubMed
Wetzel, M.C., Howell, L.G., and Bearie, K.G. (1969). Experimental performance of steel and platinum electrodes with chronic monophasic stimulation of the brain. J. Neurosurg., 31:658-669.CrossRefGoogle ScholarPubMed