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Cerebrospinal Fluid Pressure and Prolactin in Empty Sella Syndrome

Published online by Cambridge University Press:  18 September 2015

Giulio Maira ,
Carmelo Anile ,
Laura De Marinis ,
Antonio Mancini  and
Antonino Barbarino
Giulio Maira*
Affiliation:
Institute of Neurosurgery and Institute of Endocrinology, Catholic University, Rome, Italy
Carmelo Anile
Affiliation:
Institute of Neurosurgery and Institute of Endocrinology, Catholic University, Rome, Italy
Laura De Marinis
Affiliation:
Institute of Neurosurgery and Institute of Endocrinology, Catholic University, Rome, Italy
Antonio Mancini
Affiliation:
Institute of Neurosurgery and Institute of Endocrinology, Catholic University, Rome, Italy
Antonino Barbarino
Affiliation:
Institute of Neurosurgery and Institute of Endocrinology, Catholic University, Rome, Italy
*
Instituto di Neurochirurgia, Policlinico Gemelli, Largo Gemelli 8, 00168 Roma, Italia
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Abstract:

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In 58 female patients with the primary empty sella (PES) syndrome, a study of the CSF dynamics was done by evaluating both the absorptive reserve by a lumbar infusion test at constant rate, and/or the ICP increase occurring during REM phase of nocturnal physiological sleep. In 33, prolactin (PRL) dynamics were also investigated evaluating both the response to sequential stimulating test with thyrotropin-releasing hormone (TRH) and metoclopramide (MCP) and/or the circadian variation of PRL levels. Impairment of CSF dynamics was found in the 84% who had a hormonal pattern characterized by an increase of the PRL response to TRH and MCP and a decrease of the PRL circadian variation. Twenty-one patients with impaired CSF dynamics underwent CSF shunting procedures with disappearance of the signs of intracranial hypertension. They also had restoration of normal PRL dynamics but the endocrine alterations improved only moderately. Altered CSF dynamics play a role in the pathogenesis of the PES syndrome. A correlation between elevated ICP and the hypothalamo-hypophyseal control of PRL secretion may exist.

Type
Special Supplement - Secreting Pituitary Adenomas
Information
Canadian Journal of Neurological Sciences , Volume 17 , Issue 1 , February 1990 , pp. 92 - 94
Copyright
Copyright © Canadian Neurological Sciences Federation 1990

References

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