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Chroma-Memo-Flow Technique for Rapid Sequential Analysis of Regional Cerebral Blood Flow (rCBF) Responses

Published online by Cambridge University Press:  18 September 2015

Jørn Overgaard
Jørn Overgaard*
Affiliation:
Neurosurgical Department, University Hospital, DK-5000 Odense C, Denmark
*
Department of Neurosurgery, Odense University Hospital, DK-5000 Odense C, Denmark
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This is the first report of a method of sequential regional cerebral blood flow (rCBF) analysis, called Croma-Memo-Flow. This technique is a computerized modification of the initial slope method of regional cerebral blood flow (rCBF init.), allowing temporal resolution of the flow pattern by calculation of the slopes of sequential segments of the initial 1-2 minutes of the Xenon-133 washout curve. The same theoretical analysis applies to this method as to the rCBF init. method. Each flow calculation is based on the slope of a discrete 16 second segment of the initial washout; and each second the segment is advanced by one second. A new flow calculation is made each second and is displayed as a color coded map on a TV screen. Each map is labelled, indicating the time in seconds following Xenon injection, and sequential rCBF changes during the clearance period can be immediately visualized. This allows for almost instantaneous analysis and display of rapid or transient rCBF responses to activation and deactivation of the cerebral cortices.

The data is stored in a 35 channel memory for deliberate replay, photography, and analysis.

Functional tests may be applied during the initial washout period and both the magnitude and chronological relationships of the evoked regional cerebrovascular responses observed. A clinical study is presented to illustrate the possibilities of applying the technique to assess cortical reactivity.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 5 , Issue 1 , February 1978 , pp. 1 - 7
Copyright
Copyright © Canadian Neurological Sciences Federation 1978

References

REFERENCES

Albert, M.L and Bear, D. (1974): Time to understand. Brain, 97, 373–384.Google Scholar
Cooper, R., Papakostopoulos, and Crow, H.J. (1975): Rapid Changes of Cortical Oxygen Associated with Motor and Cognitive Function in Man. — p.: 14.8-14.9 in: Blood Flow and Metabolism in the Brain. Ed.: Harper, A.M., Jen-nett, W.B., Miller, J.D. & Rowan, J.O. Churchill Livingstone (ISBN 0 443 01386 1).Google Scholar
Dykes, R.W., Nelson, G.P. Tanji, G.D. and Dudar, J.D. (1977): Multiple loci of evoked potentials in somatosensory cortex. Brain Research, 124, 162–167.Google Scholar
Efron, R. (1963): Temporal perception, aphasia and déjá-vu. Brain, 86, 403–424.Google Scholar
Glickstein, M. (1972): Brain Mechanisms in Reaction Time Brain Research, 40, 33–37.Google Scholar
Hjelm, M., Overgaard, J., Lassen, N.A. and Tweed, W.A. (1975): Brain Tissue Lactacidosis of Hyperemic Regions around Brain Tumors, in: Blood Flow and Metabolism in the Brain. — ed.: Harper, A.M., Jennett, W.B., Miller, J.D. & Rowan, J.O. p.: 13.41-13.42. Churchill Livingstone (ISBN 0 443 01386 1).Google Scholar
Ingvar, D.H. and Risberg, J. (1967): Increase of regional cerebral blood flow during mental effort in normals and in patients with focal brain disorders. Expt. Br. Res: 5, 72–78.Google Scholar
Ingvar, D.H. and Gustafson, L. (1970): Regional Cerebral Blood Flow in Organic Dementia with early onset. Acta Neurol. Scand: Suppl. 43, vol. 46, 42–73Google Scholar
Ingvar, D.H. and Franzen, G. (1974): Abnormalities of Cerebral Blood Flow Distribution in Patients with Chronic Schizophrenia Acta phychiatr, scand., 50, 425–462.Google Scholar
Ingvar, D.H. and Ciria, H.G. (1975): Assessment of severe damage to the brain by multiregional measurements of cerebral blood flow, p.: 97–120. in: Outcome of Severe Damage to the Central Nervous System; Ciba Foundation Symposium 34 (new series). Elsevier — Excerpta Medica — North Holland, Amsterdam. (ISBN 90 219 4038 8 and 0444-15182-6)Google Scholar
Ingvar, D.H. (1976): Functional Landscapes of the dominant Hemisphere. Brain Research, 107, 181–197.Google Scholar
Larsen, B., Endo, H. and Lassen, N.A. (1976): Patterns of Activation of the Human Cerebral Cortex as Evidenced by Changes in Regional Cerebral Blood Flow. Acta Physiol. Scand. 96/3 (D 13).Google Scholar
Lassen, N.A. and Ingvar, D.H. (1972): Radioisotopic Assessment of Regional Cerebral Blood Flow. Progr. nucl. Med., vol. 1, 376–409.Google ScholarPubMed
Mosfeldt Laursen, A. (1967): Higher Functions of the Central Nervous System. An. Review of Physiology, vol. 29, 543–572.Google Scholar
Olesen, J. (1971): Contralateral Focal Increase of Cerebral Blood Flow in Man During Arm Work. Brain, 94, 635–646.CrossRefGoogle ScholarPubMed
Olesen, J., Paulson, O.B. and Lassen, N.A. (1971): Regional Cerebral Blood Flow in Man Determined by the Initial Slope of the Clearance of Intraarterially Injected 133-Xe. Stroke, vol. 2, 519–540.Google Scholar
Raichle, M.E., Grubb, R.L., Gado, M. H., Eichling, J.O. and Ter-Pogossian, M.M. (1976): Correlation Between Regional Cerebral Blood Flow and Oxidative Metabolism, — In Vivo Studies in Man. Arch, Neurol., vol. 33, 523–526.Google Scholar
Risberg, J. and Ingvar, D.H. (1973): Patterns of activation in gray matter of the dominant hemisphere during memorizing and reasoning. Brain, 96, 737–756.Google Scholar
Roland, P.E. and Larsen, B. (1976): Focal Increase of Cerebral Blood Flow During Stereognostic Testing in Man. Arch. Neurol, vol. 33, 551–558.Google Scholar
Severinghaus, J.W. (Ed) (1975): Coupling Mechanisms, Flow to Function and Metabolism in Brain, a General Discussion, p. 503–517 in Symposium, Alfred Benzon VIII, Brain Work, The Coupling of Function, Metabolism and Blood Flow in the Brain. — Ed. by Ingvar, D.H. & Lassen, N.A., Munksgazrd, Copenhagen. (ISBN 0 12 - 371050 - 2).Google Scholar
Sveinsdottir, E., Larsen, B., Rom-Mer, P. and Lassen, N.A. (1977): A Multidetector Scintillation Camera with 254 Channels. J. Nucl. Med., 18, nr. 2, 168–174.Google Scholar
Zierler, K.L. (1965): Equations for Measuring Blood Flow by External Monitoring of Radioisotopes. Circ. Res. vol. 16, 309–321.Google Scholar