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Clinical Sub-Groups of Multiple Sclerosis in Relation to HLA: DR Alleles as Possible Markers of Disease Progression

Published online by Cambridge University Press:  18 September 2015

Pierre Duquette ,
Francine Décary ,
Juliana Pleines ,
Denise Boivin ,
Gilles Lamoureux ,
James B.R. Cosgrove  and
Yves Lapierre
Pierre Duquette*
Affiliation:
Hôpital Notre-Dame, Montréal
Francine Décary
Affiliation:
Canadian Red Cross, Montréal
Juliana Pleines
Affiliation:
Hôpital Notre-Dame, Montréal
Denise Boivin
Affiliation:
Canadian Red Cross, Montréal
Gilles Lamoureux
Affiliation:
Institut Armand Frappier, Montréal
James B.R. Cosgrove
Affiliation:
Neurological Institute, Montréal
Yves Lapierre
Affiliation:
Neurological Institute, Montréal
*
Hôpital Notre Dame. 1560 Est Rue Sherbrooke. Montreal. Quebec. Canada H2L 4NI
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Abstract:

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We have examined the distribution of HLA antigens in 70 multiple sclerosis (MS) patients divided in three groups defined according to clinical criteria: benign MS, severe MS, cerebellar MS. We have found a significant association between severe MS and HLA-DR2, and between benign MS of more than 15 years of evolution and HLA-DR3. We review previous work along the same line and conclude that the association of HLA antigens with “clinical subgroups of MS” could indicate a genetically based heterogeneity of the disease and offer help in establishing a prognosis.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 12 , Issue 2 , May 1985 , pp. 106 - 110
Copyright
Copyright © Canadian Neurological Sciences Federation 1985

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