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Cognitive Assessment in Alzheimer's Disease: Cross-Sectional and Longitudinal Perspectives

Published online by Cambridge University Press:  18 September 2015

Alfred W. Kaszniak ,
Robert S. Wilson ,
Jacob H. Fox  and
Glenn T. Stebbins
Alfred W. Kaszniak*
Affiliation:
Department of Psychology, University of Arizona, Tucson, Arizona
Robert S. Wilson
Affiliation:
Rush Medical College, Tucson, Arizona
Jacob H. Fox
Affiliation:
Rush Medical College, Tucson, Arizona
Glenn T. Stebbins
Affiliation:
Department of Psychology, University of Arizona, Tucson, Arizona
*
Department of Psychology, University of Arizona, Tucson Arizona, U.S.A. 85721
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Abstract:

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This paper describes select results of a longitudinal study of 62 mild to moderate Alzheimer's disease (AD) patients, in comparison to 60 age-matched healthy controls. Initial neurologic, radiologic, psychiatric, laboratory and cognitive examinations, required two full days, followed by one-day examinations at annual intervals. Of the total original sample, 31 AD patients and 39 controls could actually be followed for three annual examinations. Cognitive examination data confirmed cross-sectional (group discriminative) validity of memory and language measures, and showed the expected longitudinal deterioration in the AD sample, with controls maintaining consistent performance over the three years. However, those measures showing largest group differences at initial examination were not the best for tracking patient deterioration over time. Implications of these results for the selection of cognitive assessment measures are discussed.

Type
Neuropsychological Challenges
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue S4 , November 1986 , pp. 420 - 423
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

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