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Comparison of Counts of Neurons in the Locus Coeruleus Made From Serial Sections and From a Single Section at the Centre of the Nucleus

Published online by Cambridge University Press:  18 September 2015

C.Q. Mountjoy  and
W. Bondareff
C.Q. Mountjoy
Affiliation:
Department of Psychiatry, University of Cambridge Clinical School, and St. Andrew's Hospital, Northampton, England
W. Bondareff*
Affiliation:
Department of Psychiatry and Andrus Gerontology Centre, University of Southern California, Los Angeles, California
*
Department of Psychiatry, University of Southern California School of Medicine, Los Angeles, California, U.S.A.
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Abstract:

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This paper describes the comparability of counts in the locus coeruleus made from serial sections and those made from a single section at the point of greatest density of neurons. Samples of the locus coeruleus neuronal population derived from single section counts though not exactly comparable, are of comparable utility to those obtained from more laborious total neuronal counts. The simpler method was used to examine the hypothesis that there are subtypes of senile dementia of the Alzheimer type. Separation into two groups was achieved when independent variables of cortical neuronal counts and tangle estimates were used. This finding adds to the growing evidence that Alzheimer's disease of the senile type is not a unitary disorder.

Type
Cellular Clues to Pathogenesis
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue S4 , November 1986 , pp. 480 - 482
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

References

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