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Contribution of chromosome 9p deletion and Bcl1, Myc and p16 immunohistochemistry to the characterization of oligodendrogliomas

Published online by Cambridge University Press:  25 May 2018

P.V. Gould ,
K. Michaud ,
M. de Tayrac ,
M. D’Astous ,
C. Paquet  and
S. Saikali
P.V. Gould
Affiliation:
Service de pathologie, CHU de Québec, Québec, Canada
K. Michaud
Affiliation:
Service de neurochirurgie, CHU de Québec, Québec, Canada
M. de Tayrac
Affiliation:
Department of genomic and molecular genetics, CHU de Rennes, Rennes, France
M. D’Astous
Affiliation:
Service de neurochirurgie, CHU de Québec, Québec, Canada
C. Paquet
Affiliation:
Service de pathologie, CHU de Québec, Québec, Canada
S. Saikali
Affiliation:
Service de pathologie, CHU de Québec, Québec, Canada
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Abstract

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Molecular studies suggest that anaplastic oligodendrogliomas (OIII) can be subdivided into clinically relevant subgroups. We analyzed a retrospective series of 40 consecutive OIII operated at our institution and compared them to 10 grade II oligodendrogliomas (OII). Chromosome 9p status was compared to Bcl1, Myc and p16 expression by immunohistochemistry, clinical and histological data, and to event free survival (EFS) and overall survival (OS).

Chromosome 9p deletion was observed in 55 % of OIII (22/40) but not in OII, and correlated with both OS and EFS. Bcl1 expression was significantly higher in OIII (45 % versus 14% for OII) and correlated with MIB-1 expression, vascular proliferation, tumour necrosis and a shorter EFS. Myc expression was correlated with histologic grade (27% in OII, 35% in OIII) and to a shorter EFS in chromosome 9p non-deleted OIII. p16 expression was not correlated with grade but revealed two distinct expression profiles according to chromosome 9p status. In 9p non-deleted oligodendrogliomas, p16 hyperexpression was correlated with shorter OS in both OII and OIII whereas absence of p16 expression was correlated with shorter OS and EFS in 9p deleted OIII.

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Abstracts
Information
Canadian Journal of Neurological Sciences , Volume 45 , Supplement S1: ABSTRACTS: 57th Annual Canadian Association of Neuropathologists Meeting , May 2018 , pp. S3
Copyright
Copyright © The Canadian Journal of Neurological Sciences Inc. 2018