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Correlations Histopathologiques et Neurochimiques en Fonction de Lesions de la Regiondu Locus Coeruleus chez le Chat* (Part I)

Published online by Cambridge University Press:  18 September 2015

R. Marchand ,
M. Fantino ,
J. Dankova  and
L.J. Poirier
R. Marchand
Affiliation:
Laboratoires đe Neurobiologie, Hôpital de l'Enfant-Jésus et Faculté de Médecine, Université Laval, Québec, Qué. Canada
M. Fantino
Affiliation:
Laboratoires đe Neurobiologie, Hôpital de l'Enfant-Jésus et Faculté de Médecine, Université Laval, Québec, Qué. Canada
J. Dankova*
Affiliation:
Laboratoires đe Neurobiologie, Hôpital de l'Enfant-Jésus et Faculté de Médecine, Université Laval, Québec, Qué. Canada
L.J. Poirier
Affiliation:
Laboratoires đe Neurobiologie, Hôpital de l'Enfant-Jésus et Faculté de Médecine, Université Laval, Québec, Qué. Canada
*
Laboratoires de Neurobiologie, Pavillon Notre-Dame, 2075 ave de Vitré, Québec, Qué. GIJ 5B3.
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Summary

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Unilateral lesions in the area of the loci coeruleus and subcoeruleus in the cat are associated with a significant and sustained decrease of noradrenaline (NA) in the ipsilateral cerebral cortex without any important change in the concentrations of NA in the contralateral cortex and in the spinal cord of both sides. The serotonin (5-HT) concentrations of the spinal cord and cerebral cortex of both sides remained unchanged in the same groups of animals. Bilateral lesions in the same area result also in a marked decrease of NA in the cerebral cortex of both sides. The latter lesions also result in slight decreases of NA in the hypothalamus and of NA and 5-HT in the spinal cord but the NA and 5-HT concentrations of the stria-turn and thalamus and the 5-H T concentrations of the cerebral cortex and hypothalamus are unmodified by such lesions. Unilateral lesions of the area immediately rostral to the locus coeruleus (praelocus lesions) result in a very significant decrease of NA in the ipsilateral cerebral cortex without any change of NA in the contralateral cerebral cortex and spinal cord of both sides. Similar lesions produced bilaterally in another group of cats resulted in marked decreases of NA in the cerebral cortex of both sides and a slight decrease of NA in the thalamus without any change of NA in the striatum, hypothalamus and spinal cord and of 5-HT in the cerebral cortex. In the same group of animals with lesions which, however, extended more closely to the midline than in cats with locus coeruleus lesions, 5-HT is markedly decreased in the striatum and thalamus and slightly decreased in the hypothalamus and spinal cord.

These results support the view that the noradrenergie coeruleo-cortical pathway is made up of fibers which originate in the loci coeruleus and subcoeruleus and pre-dominently end ipsilaterally to their origin in the cerebral cortex. Ascending NA fibers ending in the thalamus appear to originate from NA neurons located more laterally in the upper pons and more specifically at the level of the parabrachial nuclei.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 6 , Issue 1 , February 1979 , pp. 27 - 37
Copyright
Copyright © Canadian Neurological Sciences Federation 1979

Footnotes

*

Supported by grant MT-732 from the Medical Research Council of Canada.

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