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Creutzfeldt-Jakob Disease: Correlation of Focal Electroencephalographic Abnormalities and Clinical Signs

Published online by Cambridge University Press:  18 September 2015

Douglas E. Eggertson  and
Neelan Pillay
Douglas E. Eggertson
Affiliation:
Section of Neurology, Department of Medicine, Health Sciences Centre and University of Manitoba, Winnipeg, Manitoba, Canada
Neelan Pillay*
Affiliation:
Section of Neurology, Department of Medicine, Health Sciences Centre and University of Manitoba, Winnipeg, Manitoba, Canada
*
Department of Neurology, Health Sciences Centre, 700 William Avenue, Winnipeg, Manitoba, R3E 0Z3
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Abstract:

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Three patients are described with pathologically verified Creutzfeldt-Jakob disease (CJD) who presented with localizing clinical signs accompanied by focal electroencephalographic abnormalities including periodic lateralized epileptiform discharges (PLEDS). With further progression of the disease, diffuse background slowing and continuous bisynchronous periodic discharges appeared in all three cases. There was good correlation between the initial focal clinical manifestations and the EEG findings.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue 2 , May 1986 , pp. 120 - 124
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

References

REFERENCES

1.Jones, DP, Nevin, S.Rapidly progressive cerebral degeneration (subacute vascular encephalopathy) with mental disorder, focal disturbances and myoclonic epilepsy. J Neurol Neurosurg Psychiatry 1954; 17: 142–189.CrossRefGoogle ScholarPubMed
2.Burger, LJ, Rowan, AJ, and Goldensohn, ES.Creutzfeldt-Jakob disease: An electroencephalographic study. Arch Neurol 1972; 26: 428–433.CrossRefGoogle ScholarPubMed
3.Chiofalo, N, Fuentes, A, Galvez, S.Serial EEG findings in 27 cases of Creutzfeldt-Jakob disease. Arch Neurol 1980; 37: 143–145.CrossRefGoogle ScholarPubMed
4.Lee, RG and Blair, RDG.Evolution of EEG and visual evoked response changes in Jakob-Creutzfeldt disease. Electroenceph Clin Neurophysiol 1973; 35: 133–142.CrossRefGoogle ScholarPubMed
5.Au, WJ, Gabor, AJ, Vijayan, N, et al. Periodic lateralized epilepti form complexes (PLEDs) in Creutzfeldt-Jakob disease. Neurology 1980; 30: 611–617.CrossRefGoogle Scholar
6.Furlan, A, Henry, CE, Sweeny, PI, et al. Focal EEG abnormalities in Heidenhain’s variant of Creutzfeldt-Jakob disease. Arch Neurol 1981; 38: 312–314.CrossRefGoogle Scholar
7.Goto, K, Umezaki, H, Suetsugu, M.Electroencephalographic and clinicopathological studies on Creutzfeldt-Jakob syndrome. J Neurol Neurosurg Psychiatry 1976; 39: 931–940.CrossRefGoogle ScholarPubMed
8.Chiappa, KH, Burke, CJ, Young, RR.Creutzfeldt-Jakob disease: Periodic sharp waves in the EEG as an invariant element of the clinical syndrome. Neurology 1979; 29(A): 551–552.Google Scholar
9.Nilsson, BY, Olsson, Y, Sourander, P.Electroencephalographic and histopathologic changes resembling Creutzfeldt-Jakob disease after transient cerebral ischemia due to cardiac arrest. Acta Neurol Scand 1972; 48: 416–426.CrossRefGoogle ScholarPubMed
10.Watson, CP.Clinical similarity of Alzheimer and Creutzfeldt-Jakob disease. Ann Neurol 1979; 6: 368–369.CrossRefGoogle ScholarPubMed
11.Gloor, P.EEG characteristics in Creutzfeldt-Jakob disease. Ann Neurol 1980; 8: 341.CrossRefGoogle ScholarPubMed
12.Chatrian, GE, Shaw, CM, Leffman, H.The significance of periodic lateralized epileptiform discharges in EEG: An electrographic clinical and pathological study. ElectroencephClin Neurophysiol 1964; 17: 177–193.CrossRefGoogle ScholarPubMed
13.Ellian, M.Herpes simplex virus encephalitis and the EEG. J Electrophysiol Technol 1975; 1: 161–170.Google Scholar
14.Upton, A, Gumpert, J.Electroencephalography in diagnosis of herpes simplex encephalitis. Lancet 1970; 1: 650–652.CrossRefGoogle ScholarPubMed
15.Paz, D, Brenner, RP.Bilateral independent periodic lateralized epileptiformdischarges. Clinical significance. Arch Neurol 1981; 38: 713–715.CrossRefGoogle ScholarPubMed
16.Brown, P, Cathala, F, Sadowsky, D, et al. Creutzfeldt-Jakob disease in France: II. Clinical characteristics of 124 consecutive verified cases during the decade 1968–1977. Ann Neurol 1979;6:430–437.CrossRefGoogle ScholarPubMed
17.Roos, R, Gajdusek, DC, Gibbs, CJ.The clinical characteristics of transmissible Creutzfeldt-Jakob disease. Brain 1973; 96: 1–20.Google ScholarPubMed
18.Gomori, AJ, Partnow, MJ, Horoupian, DJet al. The ataxic form of Creutzfeldt-Jakob disease. Arch Neurol 1973; 29: 318–323.CrossRefGoogle ScholarPubMed
19.Meyer, A, Leigh, D, Bagg, CE.A rare presenile dementia associated with cortical blindness (Heidenhain’s syndrome). J Neurol Neurosurg Psychiatry 1954; 17: 129–133.CrossRefGoogle ScholarPubMed