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Cushing’s Disease: 50 Years Later

Published online by Cambridge University Press:  18 September 2015

Jules Hardy
Jules Hardy*
Affiliation:
Division of Neurosurgery, Faculty of Medicine, University of Montreal
*
1386 Sherbrooke E., Montreal, P.Q., Canada H2L 1M4
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Summary:

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The recent improvements in transsphenoidal microsurgery have once again placed the emphasis on the basophilic adenoma of the pituitary as the etiology of the disease originally described by Harvey Cushing fifty years ago.

In 75 operated cases, tumors were found in 60 cases: 52 were microadenomas, 4 were larger adenomas and 4 were invasive. In 15 cases, no tumor was found at surgery; a selective partial central hypophysectomy was performed in 11 cases and a total hypophysectomy in 4. Among the latter, 3 additional microadenomas were found at pathology. The majority of the microadenomas were located in the center of the gland most often near or within the neural lobe.

In 59 patients with a non invasive tumor, initial cure was obtained in 52 (88%); only 1 of the 4 patients with an invasive tumor was cured.

In the 12 cases without surgical or pathological tumor, partial or total hypophysectomy resulted in 10 cures (83%).

Type
Presidential Address: XVII Canadian Congress of Neurological Sciences
Information
Canadian Journal of Neurological Sciences , Volume 9 , Issue 4 , November 1982 , pp. 375 - 380
Copyright
Copyright © Canadian Neurological Sciences Federation 1982

References

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