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Dendritic Pathology: An Overview of Golgi Studies in Man

Published online by Cambridge University Press:  18 September 2015

Venkita Jagadha  and
Laurence E. Becker
Venkita Jagadha
Affiliation:
Division of Neuropathology (Department of Pathology), The Hospital for Sick Children and the University of Toronto, Toronto
Laurence E. Becker*
Affiliation:
Division of Neuropathology (Department of Pathology), The Hospital for Sick Children and the University of Toronto, Toronto
*
Division of Neuropathology, The Hospital for Sick Children, 555 University Ave., Toronto, Ontario, Canada M5G 1X8
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Abstract:

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Study of dendritic morphology through Golgi impregnation techniques has significantly furthered our understanding of neuronal development, maturation, and senescence. It has also provided insight into the pathogenesis of a wide spectrum of disease processes ranging from brain malformations to degenerative disorders. Golgi impregnation remains virtually the only method for demonstrating dendritic morphology. It delineates the profile of the individual neuron and its dendritic ramifications with unsurpassed clarity. Although it has been widely applied to experimental neuroscience involving animal tissue, its application to human material has been limited. This review summarizes the information on dendritic development and pathology in the human brain revealed by the use of the Golgi method.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 16 , Issue 1 , February 1989 , pp. 41 - 50
Copyright
Copyright © Canadian Neurological Sciences Federation 1989

References

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