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Dopamine Uptake Capacity of Platelets From People At Risk For Huntington’s Chorea

Published online by Cambridge University Press:  18 September 2015

Donald R. McLean  and
Taichi Nihei
Donald R. McLean*
Affiliation:
Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta
Taichi Nihei*
Affiliation:
Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta
*
9-101 Clinical Sciences Building, The University of Alberta, Edmonton, Alberta, Canada T6G 2G3
9-101 Clinical Sciences Building, The University of Alberta, Edmonton, Alberta, Canada T6G 2G3
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Summary:

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Dopamine (DA) uptake by platelets from 41 patients at risk to develop Huntington’s chorea was assayed and compared to controls. The DA uptake was significantly higher in the at risk group. However, the at risk group did not separate into two distinct subgroups. which reduces the usefulness of the assay as a disease prognosticator.

Type
Articles
Information
Canadian Journal of Neurological Sciences , Volume 8 , Issue 2 , May 1981 , pp. 167 - 168
Copyright
Copyright © Canadian Neurological Sciences Federation 1981

References

Amimoff, M.J., Trenchard, A., Turner, P.et al. (1974). Plasma uptake of dopamine and 5HT and plasma catecholamine levels in patients with Huntington’s chorea. Lancet II (1879). 1115–1116.CrossRefGoogle Scholar
Mclean, D.R., Nihei, T. (1977). Uptake of dopamine and 5 – hydroxytryptamine in platelets from patients with Huntington’s chorea. Lancet I (8005), 249–250.CrossRefGoogle Scholar
Mclean, D.R., Nihei, T. (1980). Biochemical markers for Huntington’s chorea. Can. J. Neurol. Sci., 7, 281–283.CrossRefGoogle ScholarPubMed
Nichols, J.W., Deamer, D.W. (1976). Biochim. Biophys. Acta. 455, 269–271.CrossRefGoogle Scholar
Solomon, H.M., Spirt, N.M., Abrams, W.B. (1970). Clin. Pharmacol. Therapeut., 11,838–845.CrossRefGoogle Scholar