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Effect of Phenytoin on Protein Binding of Valproic Acid

Published online by Cambridge University Press:  18 September 2015

J. Bruni ,
J.M. Gallo  and
B.J. Wilder
J. Bruni*
Affiliation:
Department of Neurology, College of Medicine and College of Pharmacy, University of Florida, Gainesville, Florida
J.M. Gallo
Affiliation:
Department of Neurology, College of Medicine and College of Pharmacy, University of Florida, Gainesville, Florida
B.J. Wilder
Affiliation:
Department of Neurology, College of Medicine and College of Pharmacy, University of Florida, Gainesville, Florida
*
Jones Building, Wellesley Hospital, 160 Wellesley St. East, Toronto, Ontario, M4Y 1J3, Canada
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In vitro experiments using the equilibrium dialysis technique were performed to determine the binding of valproic acid to plasma components in the absence and presence of therapeutic concentrations of phenytoin. The free fraction of valproic acid was found to be dependent on the total valproic acid concentration. Phenytoin did not influence valproic acid protein binding.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 6 , Issue 4 , November 1979 , pp. 453 - 454
Copyright
Copyright © Canadian Neurological Sciences Federation 1979

References

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