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The Effects of Local Cooling on Canine Spinal Cord Blood Flow

Published online by Cambridge University Press:  18 September 2015

Robert R. Hansebout ,
R. Neil Lamont  and
M. Venkatraya Kamath
Robert R. Hansebout*
Affiliation:
Departments of Surgery and Neurosciences, McMaster University, Hamilton
R. Neil Lamont
Affiliation:
Departments of Surgery and Neurosciences, McMaster University, Hamilton
M. Venkatraya Kamath
Affiliation:
Departments of Surgery and Neurosciences, McMaster University, Hamilton
*
Department of Surgery, St.Joseph’s Hospital, 50 Charlton Ave., E., Hamilton, Ontario, Canada L8N 4A6
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Abstract:

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The internal spinal cord blood flow was measured in dogs at the site of local cooling using hydrogen polarography. Blood flow decreased to 50% of the normothermic values during cooling of the cord to a central temperature of 16 degrees Celsius. Upon cessation of cooling internal blood flow rapidly returned to normal values. Implications of this finding for the treatment of spinal cord injury are discussed.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 12 , Issue 2 , May 1985 , pp. 83 - 87
Copyright
Copyright © Canadian Neurological Sciences Federation 1985

References

1.Hansebout, RR.A comprehensive review of methods of improving cord recovery after acute spinal cord injury. In: Tator, CH., ed. Early Management of Acute Spinal Cord Injury. Semin Neurol Surg, New York: Raven Press, 1982; pp 181–196.Google Scholar
2.Wells, JD., Hansebout, RR.Local hypothermia in experimental spinal cord trauma. Surg Neurol 1978; 10: 200–204.Google ScholarPubMed
3.Bingham, WG., Goldman, H., Friedman, SJ., et al. Blood flow in normal and injured monkey spinal cord. J Neurosurg 1975; 43: 162–171.CrossRefGoogle ScholarPubMed
4.Kobrine, AI., Evans, DE., Rizzoli, H.Correlation of spinal cord blood flow and function in experimental compression. Surg Neurol 1978; 10: 54–59.Google ScholarPubMed
5.Tator, CH.Acute spinal cord injury: A review of recent studies of treatment and pathophysiology. Can Med Assoc J 1972; 107: 143–150.Google ScholarPubMed
6.Zielonka, JS., Wagner, FC., Dohrmann, GJ.Alterations in spinal cord blood flow during local hypothermia. Surg Forum 1974;25: 434–435.Google ScholarPubMed
7.Meyer, JD., Hunter, J.Effects of hypothermia on local blood flow and metabolism during cerebral ischemia and hypoxia. J Neurosurg 1957; 14: 210–227.CrossRefGoogle ScholarPubMed
8.Romero-Sierra, C., Hansebout, R., Sierhuis, A., et al. A new method for localised spinal-cord cooling. Med Biol Eng 1974; 12: 188–193.CrossRefGoogle ScholarPubMed
9.Aukland, K.Hydrogen polarography in measurement of local blood flow: theoretical and empirical basis. Acta Neurol Scand [Suppl] 1965; 14: 42–46.Google Scholar
10.Aukland, K., Bower, BF., Berliner, RW.Measurement of local blood flow with hydrogen gas. Circ Res 1964; 14: 164–187.CrossRefGoogle ScholarPubMed
11.Senter, HJ., Burgess, DH., Metzler, J.An improved technique for measurement of spinal cord blood flow. Brain Res 1978; 149: 197–203.CrossRefGoogle ScholarPubMed
12.Geddes, LA.Electrodes and the Measurement of Bioelectric Events. Toronto: Wiley & Sons Inc., 1972; pp 139–140.Google Scholar
13.Griffiths, IR., Rowan, JO.Spinal cord blood flow measured by a hydrogen clearance technique. J Neurol Sci 1975; 26: 529–544.CrossRefGoogle ScholarPubMed
14.Kobrine, AI., Doyle, TF., Martins, AN.Spinal cord blood flow in the rhesus monkey by the hydrogen clearance method. Surg Neurol 1974; 2: 197–200.Google ScholarPubMed
15.Rosomoff, HL.Protective effects of hypothermia against pathological processes of the nervous system. Ann Ny Acad Sci 1959; 80: 475–486.CrossRefGoogle ScholarPubMed
16.Janssens, WJ., Vanhoutte, PM.Instantaneous changes of alpha-adrenoceptor affinity caused by moderate cooling in canine cutaneous veins. Am J Physiol 1978; 234: H330–H337.Google ScholarPubMed
17.Astrup, J.Energy-requiring cell functions in the ischemic brain. J Neurosur 1982; 56: 482–497.CrossRefGoogle ScholarPubMed
18.Scuotto, A., Borriello, R., Paggio, G.Valuation of some biological parameters in acute spinal cord trauma: experimental study. Presented at Seminar On Spinal Cord Reconstruction, Auditorium Museo di Capodimonte, Naples, Italy, October 21, 1983.Google Scholar
19.Kobrine, AI., Doyle, TF., Martins, AN.Local spinal cord blood flow in experimental traumatic myelopathy. J Neurosurg 1975; 42: 144–149.CrossRefGoogle ScholarPubMed