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β-Endorphin in Multiple Trauma Victims

Published online by Cambridge University Press:  18 September 2015

R. Guieu ,
C. Devaux ,
J. Albanese ,
C. Martin ,
M. Juin  and
H. Rochat
R. Guieu*
Affiliation:
Laboratoire de Biochimie, CNRS URA 1455, Faculté de Médecine Secteur Nord, Bd P Dramard, Marseille, France
C. Devaux
Affiliation:
Laboratoire de Biochimie, CNRS URA 1455, Faculté de Médecine Secteur Nord, Bd P Dramard, Marseille, France
J. Albanese
Affiliation:
Service de Réanimation Polyvalente, Marseille, France
C. Martin
Affiliation:
Service de Réanimation Polyvalente, Marseille, France
M. Juin
Affiliation:
Laboratoire de Biochimie, CNRS URA 1455, Faculté de Médecine Secteur Nord, Bd P Dramard, Marseille, France
H. Rochat
Affiliation:
Laboratoire de Biochimie, CNRS URA 1455, Faculté de Médecine Secteur Nord, Bd P Dramard, Marseille, France
*
Laboratoire de Biochimie, CNRS URA 1455. Faculté de Médecine Secteur Nord, Bd P Dramard 13916 Marseille Cedex 20, France
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Abstract

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Background:

In animals and in humans, stress is known to be accompanied by increased β-endorphin secretion.

Methods:

Blood samples from 47 patients in a state of stress induced by multiple trauma were assessed for β-endorphin concentration by radioimmunoassays.

Results:

We show that there is a clearcut correlation (Spearman’s R = 0.72, P = 2.1 x 10”-6) between the level of consciousness evaluated with the Glasgow score and levels of circulating β-endorphin. In addition, β-endorphin levels are higher than normal in patients with Glasgow coma with scores higher than seven, and lower than normal in those with Glasgow coma scores of seven or less. Finally, in the complete absence of stress (shown by the lack of brain activity in six irreversible coma patients), there is a severe drop in the level of circulating β-endorphin.

Conclusion:

β-endorphin serum levels correlate with the state of consciousness of multiple trauma patients.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 22 , Issue 2 , May 1995 , pp. 160 - 163
Copyright
Copyright © Canadian Neurological Sciences Federation 1995

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