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Facilitation of Kindled Seizures in Rats Fed Choline-Supplemented Diets

Published online by Cambridge University Press:  18 September 2015

Kevin McCann ,
Donald P. Cain  and
Diana J. Philbrick
Kevin McCann
Affiliation:
Departments of Psychology and Physiology, University of Western Ontario, London, Ontario
Donald P. Cain*
Affiliation:
Departments of Psychology and Physiology, University of Western Ontario, London, Ontario
Diana J. Philbrick
Affiliation:
Departments of Psychology and Physiology, University of Western Ontario, London, Ontario
*
Department of Psychology, University of Western Ontario, London, Ontario N6A 5C2.
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Different groups of rats were maintained on choline-deprived (CD), choline-supplemented (CS) or standard rat chow diets beginning at a body weight of approximately 100 g, and electrically kindled in the amygdala beginning not less than 40 days later. The CS group kindled significantly faster than the CD group, whereas the CD and chow-fed groups did not differ in their rate of kindling. This result is consistent with both the known effects of the dietary manipulation of choline on brain acetylcholine level, and the idea that acetylcholine has a role in amygdaloid kindling.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 10 , Issue 1 , February 1983 , pp. 47 - 49
Copyright
Copyright © Canadian Neurological Sciences Federation 1983

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