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Familial Alzheimer's Disease

Published online by Cambridge University Press:  18 September 2015

A.D. Sadovnick ,
H. Tuokko ,
A. Horton ,
P.A. Baird ,
B.L. Beattie  and
Sanford M. Spiegel
A.D. Sadovnick*
Affiliation:
Department of Medical Genetics, University of British Columbia, and the Clinic for Alzheimer's Disease and Related Disorders, Health Sciences Centre Hospital, Vancouver, British Columbia
H. Tuokko
Affiliation:
Department of Psychology, University of British Columbia, and the Clinic for Alzheimer's Disease and Related Disorders, Health Sciences Centre Hospital, Vancouver, British Columbia
A. Horton
Affiliation:
Department of Psychiatry, University of British Columbia, and the Clinic for Alzheimer's Disease and Related Disorders, Health Sciences Centre Hospital, Vancouver, British Columbia
P.A. Baird
Affiliation:
Department of Medical Genetics, University of British Columbia, and the Clinic for Alzheimer's Disease and Related Disorders, Health Sciences Centre Hospital, Vancouver, British Columbia
B.L. Beattie
Affiliation:
Department of Medicine, University of British Columbia, and the Clinic for Alzheimer's Disease and Related Disorders, Health Sciences Centre Hospital, Vancouver, British Columbia
Sanford M. Spiegel
Affiliation:
Department of Medical Genetics, University of British Columbia, and the Clinic for Alzheimer's Disease and Related Disorders, Health Sciences Centre Hospital, Vancouver, British Columbia
*
Department of Medical Genetics, University of British Columbia, 6174 University Blvd., Vancouver, British Columbia, Canada V6T 1W5
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Abstract:

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A family with familial Alzheimer's disease (FAD) inherited as an apparent autosomal dominant trait is presented. Twelve individuals (6 females; 6 males) in 4 generations were affected. The disease had its onset in the late 30's, early 40's with death by age 50. Although FAD which appears to be transmitted as an autosomal dominant trait is relatively rare, such families must be identified and carefully counselled with respect to recurrence risks for subsequent generations. In this family, there are currently 20 members of Generation IV, aged 15-37, and 9 members of Generation V, aged 1-11. The majority of these individuals appear to have a 50% risk for developing this disease.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 15 , Issue 2 , May 1988 , pp. 142 - 146
Copyright
Copyright © Canadian Neurological Sciences Federation 1988

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