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Function of the Basal Ganglia as Revealed by Cognitive and Motor Disorders in Parkinson’s Disease

Published online by Cambridge University Press:  18 September 2015

C.D. Marsden
C.D. Marsden*
Affiliation:
University Department of Neurology, Institute of Psychiatry and King’s College Hospital, London
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Abstract

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Early Parkinson’s disease is taken to be the best human model of disordered basal ganglia function. An experimental study in Parkinsonians with swings in motor response to drug treatment suggests that general cognition is not controlled by dopamine mediated striatal activity. The variety of motor disorders in Parkinson’s disease cannot be explained by simple concepts. Although Parkinsonians cannot execute fast ballistic movements, an experimental study shows that they can adopt a predictive motor control strategy. It is argued that simple motor programs are not grossly disturbed in Parkinson’s disease. It is concluded that Parkinsonians cannot automatically execute learned motor plans.

Type
2. Physiology of the Basal Ganglia and Pathophysiology of Parkinson’s Disease
Information
Canadian Journal of Neurological Sciences , Volume 11 , Issue S1: Current Concepts and Controversies in Parkinson’s Disease , February 1984 , pp. 129 - 135
Copyright
Copyright © Canadian Neurological Sciences Federation 1984

References

Angel, RW, Alston, W, Higgins, JR (1970) Control of movement in Parkinson’s disease. Brain, 93:1–14.CrossRefGoogle ScholarPubMed
Brown, RG, Marsden, CD, Quinn, N, Wyke, MA (1984) Alterations in cognitive performance and affect-arousal state during fluctuations in motor function in Parkinson’s disease. J. Neurol. Neurosurg. Psychiat., in press.CrossRefGoogle Scholar
Day, BL, Marsden, CD (1982) Two strategies for learning a visually guided motor task. Perceptual and Motor Skills, 55:1003–1016.Google Scholar
Denny-Brown, D (1968) Clinical symptomatology of diseases of the basal ganglia. In “Handbook” of Clinical Neurology”, vol. 6 “Diseases of the Basal Ganglia”, pp. 133–211, North-Holland Publishing Company, Amsterdam.Google Scholar
Evarts, EV, Trevainen, H, Calne, DB (1981) Reaction time in Parkinson’s disease. Brain, 104:167–186.CrossRefGoogle ScholarPubMed
Flowers, KA (1976) Visual ‘closed-loop’ and ‘open-loop’ characteristics of voluntary movement in patients with parkinsonism and intention tremor. Brain, 99:269–310.CrossRefGoogle ScholarPubMed
Flowers, K (1978a) Some frequency response characteristics of parkinsonism on pursuit tracking. Brain, 101:19–34.CrossRefGoogle ScholarPubMed
Flowers, K (1978b) Lack of prediction in the motor behaviour of parkinsonism. Brain, 101:35–52.CrossRefGoogle ScholarPubMed
Hallett, M, Khoshbin, S (1980) A physiological mechanism of bradykinesia. Brain 103:301–304.CrossRefGoogle ScholarPubMed
Heilman, KM, Bowers, D, Watson, RT, Greer, M (1976) Reaction times in Parkinson’s disease. Arch. Neurol. (Chic), 33:139–140.CrossRefGoogle Scholar
Home, DKde, L (1973) Sensorimotor control in Parkinsonism. J. Neurol. Neurosurg. Psychiat. 36:742–746.Google Scholar
Keele, SW (1968) Movement control in skilled motor performance. Psychol. Bull., 70:387–403.CrossRefGoogle Scholar
Kornhuber, HH (1971) Motor function of the cerebellum and basal ganglia: the cerebellocortical saccadic (ballistic) clock, the cerebellonuclear hold regulator, and the basal ganglia ramp (voluntary speed smooth movement) generator. Kybernetic, 8:157–162.CrossRefGoogle Scholar
Lee, RG, Tatton, WG (1975) Motor responses to sudden limb displacements in primates with specific CNS lesions and in human patients with motor system disorders. Can. J. Neurol. Sci., 2:285–293.CrossRefGoogle ScholarPubMed
Lees, AJ, Smith, E (1983) Cognitive deficits in early stages of Parkinson’s disease. Brain, 106:257–270.CrossRefGoogle ScholarPubMed
Marsden, CD (1982) The mysterious motor function of the basal ganglia. Neurology (Minneap), 32:514–539.CrossRefGoogle ScholarPubMed
Marsden, CD (1984) Motor disorders in basal ganglia disease. Human Neurobiology, in press.CrossRefGoogle Scholar
Martin, JP (1967) “The basal ganglia and posture”. Pitman Medical Publishing Company, London.Google Scholar
Mayeux, R, Stern, Y (1983) Intellectual dysfunction and dementia in Parkinson’s disease. In “The Dementias”, eds. Mayeux, R, Rosen, WG.Advances in Neurology, 38:211–227, Raven Press, New York.Google Scholar
Perry, RH, Tomlinson, BE, Candy, JM, Blessed, G, Foster, JF, Bloxham, CA, Perry, ER (1983) Cortical cholinergic deficit in mentally impaired parkinsonian patients. Lancet, 2:789–790.CrossRefGoogle ScholarPubMed
Poirier, LJ, Pechadre, JC, Larochelle, L, Dankova, J, Boucher, R (1975) Stereotaxic lesions and movement disorders in monkeys. In “Advances in Neurology, 10, eds. Meldrum, BS, Marsden, CD, pp. 5–22, Raven Press, New York.Google Scholar
Quinn, N, Parkes, JD, Marsden, CD (1982) Complicated response fluctuations in Parkinson’s disease: Response to intravenous infusion of levodopa. Lancet, 2:412–415.CrossRefGoogle ScholarPubMed
Rothwell, JC, Obeso, JA, Traub, MM, Marsden, CD (1983) The behaviour of the long-latency stretch reflex in patients with Parkinson’s disease. J. Neurol. Neurosurg. Psychiat., 46:35–44.CrossRefGoogle ScholarPubMed
Rothwell, JC, Traub, MM, Day, BL, Obeso, JA, Thomas, PK, Marsden, CD (1982) Manual motor performance in a deafferented man. Brain, 105:515–542.CrossRefGoogle Scholar
Ruberg, M, Ploska, A, Javoy-Agid, F, Agid, Y (1982) Muscarinic binding and choline acetyltransferase activity in parkinsonian subjects with reference to dementia. Brain Res., 232:129–133.CrossRefGoogle ScholarPubMed
Schwab, RS, Talland, GA (1964) Performance with multiple sets in Parkinson’s disease. Neurology (Minneap), 9:65–72.CrossRefGoogle Scholar
Schwab, RS, Chafetz, ME, Walker, S (1954) Control of two simultaneous voluntary motor acts in normals and parkinsonism. Arch. Neurol., 72:591–598.CrossRefGoogle ScholarPubMed
Schwab, RS, England, AC, Peterson, E (1959) Akinesia in Parkinson’s disease. Neurology (Minneap), 9:65–72.CrossRefGoogle ScholarPubMed
Stern, Y, Mayeux, R, Rosen, J.Ilson, J (1982) Perceptual motor dysfunction in Parkinson’s disease: A deficit in sequential and predictive voluntary movement. J. Neurol. Neurosurg. Psychiat. 46:145–151.CrossRefGoogle Scholar
Tatton, WG, Lee, RG (1975) Evidence forabnormal long-loop reflexes in rigid Parkinsonian patients. Brain Res., 100:671–676.CrossRefGoogle ScholarPubMed
Wilson, SAK (1925) Disorders of motility and muscle tone, with special reference to the striatum. Lancet, 2:1–53, and 169. 215 and 268.Google Scholar