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Homovanillic Acid in the Cerebrospinal Fluid of Parkinsonian Patients

Published online by Cambridge University Press:  18 September 2015

L. Cunha ,
A.F. Gonçalves ,
C. Oliveira ,
M. Dinis  and
R. Amaral
L. Cunha*
Affiliation:
Clinica Neurológica, Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal
A.F. Gonçalves
Affiliation:
Clinica Neurológica, Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal
C. Oliveira
Affiliation:
Clinica Neurológica, Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal
M. Dinis
Affiliation:
Clinica Neurológica, Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal
R. Amaral
Affiliation:
Clinica Neurológica, Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal
*
Clinica Neurológica, Hospitais da Universidade de Coimbra, 3000 – Coimbra, Portugal
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Determinations of CSF HVA before and after Probenecid administration were made in 41 patients with Parkinson’s disease. The means of HVA concentration were lower than those of controls but no correlation with clinical data was found. A negative correlation was demonstrated between post-probenecid HVA levels and subsequent score improvement with L-DOPA at 3,6 and 12 months. Post-probenecid HVA levels suggest that there are distinct forms of parkinsonism and could predict the response to L-DOPA therapy.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 10 , Issue 1 , February 1983 , pp. 43 - 46
Copyright
Copyright © Canadian Neurological Sciences Federation 1983

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