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How About the New Antiepileptic Drugs?

Published online by Cambridge University Press:  18 September 2015

B.J. Wilder
B.J. Wilder*
Affiliation:
University of Florida College of Medicine, Department of Veterans Affairs Medical Center, Gainesville, Florida
*
University of Florida College of Medicine, Consultant in Neurology, Department of Veterans Affairs Medical Center, Gainesville, Florida, USA 32608-1197
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Abstract:

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No new antiepileptic drugs (AEDs) were licensed in the United States from 1978 to 1992. In late 1992, felbamate and gabapentin were recommended for approval, and in early 1993, lamotrigine. In July 1993, felbamate was licensed, and gabapentin and lamotrigine may soon follow. Lamotrigine, vigabatrin and clobazam are in use outside the US. Tiagabine, oxcarbazepine, fosphenytoin, topiramate, vigabatrin and zonisamide are in Phase II clinical testing in the US. All of the new AEDs are effective against partial and tonic-clonic seizures. Few controlled clinical trials have been done in patients with absence and myoclonic seizures. Mechanisms of action of the new drugs have not been clearly defined. The new AEDs will provide an opportunity to improve the care of epileptic patients. Even with optimal management with currently available drugs, some 30% of patients remain refractory to medical management.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 21 , Issue S3 , August 1994 , pp. S17 - S20
Copyright
Copyright © Canadian Neurological Sciences Federation 1994

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