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Impact of the Cognitive Status on the Memory Complaints in MS Patients

Published online by Cambridge University Press:  18 February 2016

M. Demers ,
I. Rouleau ,
P. Scherze ,
J. Ouellet ,
C. Jobin  and
P. Duquette
M. Demers
Affiliation:
Département de psychologie, and Institut des sciences cognitives, Université du Québec à Montréa, UQAM, Montréal, Quebec, Canada
I. Rouleau*
Affiliation:
Département de psychologie, and Institut des sciences cognitives, Université du Québec à Montréa, UQAM, Montréal, Quebec, Canada MS Clinic, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada
P. Scherze
Affiliation:
Département de psychologie, and Institut des sciences cognitives, Université du Québec à Montréa, UQAM, Montréal, Quebec, Canada
J. Ouellet
Affiliation:
Département de psychologie, and Institut des sciences cognitives, Université du Québec à Montréa, UQAM, Montréal, Quebec, Canada
C. Jobin
Affiliation:
Institut de Réadaptation Gingras-Lindsay de Montréal, Hôpital du Sacré-Coeur, Montréal, Quebec, Canada
P. Duquette*
Affiliation:
MS Clinic, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada
*
Département de psychologie, Université du Québec à Montré, CP 8888, Succ. Centre-ville, Montréal, QC, H3C 3P8, Canada
Département de psychologie, Université du Québec à Montré, CP 8888, Succ. Centre-ville, Montréal, QC, H3C 3P8, Canada
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Abstract:

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Objective:

Despite the evidence of cognitive deficits in Multiple Sclerosis (MS) patients, evaluation of their cognitive integrity is often limited to the use of clinical interviews and questionnaires. However, the consensus in the literature is that these patients under- or overestimate their deficits and repercussions. The objective of this study was to clarify why some patients overestimate while others underestimate their memory deficits.

Method:

Fifty-four participants (30 MS, 24 controls) completed the Prospective and Retrospective Memory Questionnaire (PRMQ) and were tested on a battery of neuropsychological tests. Based on the test results, MS patients were categorized as having either mild or moderate/severe cognitive deficits.

Results:

The moderate/severe MS group differed from the two other groups on the Rey Auditory Verbal Learning Test (RAVLT) but did not differ from the control group on the PRMQ. Conversely, the mild MS group did not differ from the control group on the RAVLT but did report significantly more problems than this group on the PRMQ. There was no difference between the two clinical groups on the Depression Index (Beck) but there was a significant correlation (r=.409) between the depression scores and the overestimation of prospective memory problems (PRMQ).

Conclusion:

The results explain the contradiction in the literature. It is the mild group who overestimates, maybe because they are overly concerned by their deficits, whereas the cognitive impairments of the moderate/severe group lead them to underestimate and may make their self-assessment unreliable. Formal testing or information from a significant other would be advisable.

Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 38 , Issue 5 , September 2011 , pp. 728 - 733
Copyright
Copyright © Canadian Neurological Sciences Federation 2011

References

1.Achiron, A, Barak, Y. Cognitive impairment in probable multiple sclerosis. J Neurol Neurosurg Psychiatry. 2003;74:443–6.CrossRefGoogle ScholarPubMed
2.Chiaravalloti, ND, DeLuca, J. Cognitive impairment in multiple sclerosis. Lancet Neurol. 2008;7:1139–51.CrossRefGoogle ScholarPubMed
3.DeSousa, EA, Albert, RH, Kaiman, B. Cognitive impairment in multiple sclerosis: A review. Am J Alzheimer Dis Other Demen. 2002;17:23–9.CrossRefGoogle ScholarPubMed
4.Foong, J, Rozewicz, L, Quaghebeur, G, et al.Executive function in multiple sclerosis: the role of frontal lobe pathology. Brain. 1997;120:15–26.CrossRefGoogle ScholarPubMed
5.Janculjak, D, Mubrin, Z, Brinar, V, Spilich, G. Changes of attention and memory in a group of patients with multiple sclerosis. Clin Neurol Neurosurg. 2002;104:221–7.CrossRefGoogle Scholar
6.Rao, SM, Leo, GJ, Bernardin, L, Unverzagt, F. Cognitive dysfunction in multiple sclerosis I: frequency, patterns, and prediction. Neurology. 1991;41:685–91.CrossRefGoogle ScholarPubMed
7.Brassington, JC, Marsh, NV. Neuropsychological aspects of multiple sclerosis. Neuropsychol Rev. 1998;8(2):43–77.CrossRefGoogle ScholarPubMed
8.Feinstein, A. The neuropsychiatry of multiple sclerosis. Can J Psychiatry. 2004;49(3):157–63.CrossRefGoogle ScholarPubMed
9.Reuter, F, Audoin, B, Rico, A, Malikova, I, Ranjeva, JP, Pelletier, J. Cognitive Impairment. Rev Neurol. 2009;165:S113-22.Google ScholarPubMed
10.Bravin, JH, Kinsella, GJ, Ong, B, Vowels, L. A study of performance of delayed intentions in multiple sclerosis. J Clin Exp Neuropsychol. 2000;22: 418–29.CrossRefGoogle ScholarPubMed
11.Mclntosh-Michaelis, SA, Roberts, MH, Wilkinson, SM, et al.The prevalence of cognitive impairment in a community survey of multiple sclerosis. Br J Clin Psychol. 1991;30:333–48.CrossRefGoogle Scholar
12.Rendell, PG, Jensen, F, Henry, JD. Prospective memory in multiple sclerosis. J Int Neuropsychol Soc. 2007;13:410–6.CrossRefGoogle ScholarPubMed
13.Maor, Y, Olmer, L, Mozes, B. The relationship between objective and subjective impairment in cognitive function among multiple sclerosis patients - the role of depression. Mult Scler. 2001; 17 (2):131–5.Google Scholar
14.Sherman, TE, Rapport, LJ, Ryan, KA. Awareness of deficit in multiple sclerosis. J Clin Exp Neuropsychol. 2008;30(3):301–11.CrossRefGoogle ScholarPubMed
15.Smith, G, Della Sala, S, Logie, RH, Maylor, EA. Prospective and retrospective memory in normal ageing and dementia: A questionnaire study. Memory. 2000;8(5):311–21.Google ScholarPubMed
16.Christodoulou, C, Melville, P, Scherl, WF, et al.Perceived cognitive dysfunction and observed neuropsychological performance: Longitudinal relation in persons with multiple sclerosis. J Int Neuropsychol Soc. 2005;11:614–9.CrossRefGoogle ScholarPubMed
17.Middleton, LS, Denney, DR, Lynch, SG, Parmenter, B. The relationship between perceived and objective cognitive functioning in multiple sclerosis. Arch Clin Neuropsychol. 2006; 21:487–94.CrossRefGoogle ScholarPubMed
18.McDonald, WI, Compston, A, Edan, G, et al.Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol. 2001;50:121–7.CrossRefGoogle ScholarPubMed
19.Kurtzke, JF. Rating neurological impairment in multiple sclerosis: An expanded disability status scale (EDSS). Neurology. 1983; 33:1444–52.CrossRefGoogle Scholar
20.Ouellet, J, Scherzer, PB, Rouleau, I, et al.Assessment of social cognition in patients with multiple sclerosis. J Int Neuropsychol Soc. 2010;16(2):287–96.CrossRefGoogle ScholarPubMed
21.Benedict, RBH, Fishman, I, McClellan, MM, Bakshi, R, Weinstock-Guttman, B. Validity of the Beck Depression Inventory-Fast Screen in multiple sclerosis. Multiple Sclerosis. 2003;9:393–6.CrossRefGoogle ScholarPubMed
22.Carone, DA, Benedict, RH, Munschauer, FE 3rd, Fishman, I, Weinstuck-Guttman, B. Interpreting patient/informant dis-crepencies of reported cognitive symptoms in MS. J Int Neuropsychol. Soc. 2005;ll(5):574–83.Google Scholar
23.Goverover, Y, Chiaravalloti, N, DeLuca, J. The relationship between self-awareness of neurobehavioral symptoms, cognitive functioning, and emotional symptoms in multiple sclerosis. Mult Scler. 2005;11:203–12.CrossRefGoogle ScholarPubMed
24.Julian, L, Merluzzi, NM, Mohr, DC. The relationship among depression, subjective cognitive impairment, and neuropsychological performance in multiple sclerosis. Mult Scler. 2007;13:81–6.CrossRefGoogle ScholarPubMed
25.Marrie, RA, Chelune, G J, Miller, DM, Cohen, A. Subjective cognitive complaints relate to mild impairment of cognition in multiple sclerosis. Mult Scler. 2005;11:69–75.CrossRefGoogle ScholarPubMed
26.Crawford, JR, Henry, JD, Ward, AL, Blake, J. The prospective and retrospective memory questionnaire (PRMQ): Latent structure, normative data and discrepancy analysis for proxy-ratings. Br J Psychol. 2006;45:83–104.Google ScholarPubMed