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Intellectual Performance in Multi-Infarct Dementia and Alzheimer's Disease A Replication Study

Published online by Cambridge University Press:  18 September 2015

Francisco I. Perez ,
David A. Stump ,
Joe R.A. Gay  and
Vicki R. Hart
Francisco I. Perez*
Affiliation:
Department of Neurology and Psychiatry, Baylor College of Medicine, and the Baylor-Methodist Center for Cerebrovascular Research, Houston, Texas U.S.A.
David A. Stump
Affiliation:
Department of Neurology and Psychiatry, Baylor College of Medicine, and the Baylor-Methodist Center for Cerebrovascular Research, Houston, Texas U.S.A.
Joe R.A. Gay
Affiliation:
Department of Neurology and Psychiatry, Baylor College of Medicine, and the Baylor-Methodist Center for Cerebrovascular Research, Houston, Texas U.S.A.
Vicki R. Hart
Affiliation:
Department of Neurology and Psychiatry, Baylor College of Medicine, and the Baylor-Methodist Center for Cerebrovascular Research, Houston, Texas U.S.A.
*
Department of Neurolody, Baylor College of Medicine, 1200 Moursund Avenue, Houston, Texas 77030. U.S.A.
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A consistent feature in dementia is an overall intellectual deterioration. The present study investigated the intellectual performance of patients with Alzeheimer's disease (AD) and multi-infarct dementia (MID) using the Wechsler Adult Intelligence Scale (WAIS). For reliability and generality purposes two independent samples of patients were collected. Significant differences in Education Level (EDU) and Performance IQ (PIQ) were obtained for the first sample, with the AD group having a significantly higher EDU level. The MID group obtained a higher PIQ. No significant differences were found in the second sample, but EDU level approached significance with the AD group again having a higher EDU level. A discriminant function analysis classified 81% of the patients in the first sample and 100% diagnostic accuracy was obtained for the second sample using the II predictor variables. A maximum R stepwise regression was performed in order to detect the “best” model of variables discriminating between the diagnostic groups. For the first sample the “best” model was the two variable model, including EDU and Full Scale IQ, accounting for 40% of the variance. The simplest model for the second sample was the one variable model including EDU, accounting for 20% of the variance. Quantitative, differences were found between the AD samples. Time since onset of the disease was offered as a possible influence in the quantitative differences in the AD samples. Sampling biases in the behavioral study of dementia are discussed. Successful replication was obtained.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 3 , Issue 3 , August 1976 , pp. 181 - 187
Copyright
Copyright © Canadian Neurological Sciences Federation 1976

References

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