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Investigation of the Polymorphic Region in the 5' Flanking Region of the Insulin Gene in Patients with Alzheimer's Disease

Published online by Cambridge University Press:  18 September 2015

Michael Fisman  and
Valerie M. Watt
Michael Fisman*
Affiliation:
University of Western Ontario, London, Ontario
Valerie M. Watt
Affiliation:
Department of Physiology, University of Toronto, Toronto, Ontario
*
London Psychiatric Hospital, 850 Highbury Avenue, P.O. Box 2532, Terminal “A”, London, Ontario, Canada N6A 4H1
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Abstract:

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A potential relationship between Alzheimer's Disease (AD) and insulin gene expression was suggested by the observation that patients with AD have altered levels of fasting blood sugar and insulin. Since polymorphisms in the region 5' to the insulin gene have been associated with blood glucose levels, we have studied this polymorphism in AD patients. Subjects were 19 nondiabetic AD patients with symptoms of aphasia and apraxia and a family history of AD; and 20 age and sex-matched nondiabetic controls without family history of AD. The 5' polymorphic region of the insulin gene was analyzed by restriction enzyme digestion of DNA extracted from whole venous blood. We did not observe a correlation between the size of the 5' polymorphic region and AD.

Type
Cellular Clues to Pathogenesis
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue S4 , November 1986 , pp. 471 - 474
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

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