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Le Cerveau Influence-t-il le Développement Musculaire du Foetus Humain?

Published online by Cambridge University Press:  18 September 2015

Harvey B. Sarnat
Harvey B. Sarnat*
Affiliation:
Des Départements de Pédiatrie, de Pathologie, et des Sciences Neurologiques. Université de Calgary Faculté de Médecine Travail présenté à la réunion de la Child Neurology Society (des É-U) à Phoenix, Arizona, É-U, séance du 12 octobre 1984
*
Alberta Children’s Hospital, 1820 Richmond Road S.W., Calgary. Alberta T2T 5C7
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Abstract:

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Does the human fetal brain influence muscle development? The importance of suprasegmental cerebral influence on developing human fetal muscle is less well understood than the control of histochemical differentiation of muscle by the motor neuron. Muscle biopsies of 21 hypotonic infants and children with nonprogressive congenital lesions of the cerebellum and/or brainstem were studied by histochemical methods. Two neonates who died with severely dysplastic brains and no descending motor tracts had normal muscle. The others, particularly those with cerebellar hypoplasia, had delayed muscle maturation, selective predominance of type I or II muscle fibres or disproportion in fibre sizes. It is concluded that the motor unit is capable of developing normally without suprasegmental influence, but that an abnormal balance of descending impulses may alter histochemical differentiation of fetal muscle. The small ‘subcorticospinal’ pathways arising in the brainstem probably are more influential than the larger corticospinal tract because of later myelination in the latter. The muscle biopsy thus serves to provide evidence of suprasegmental disease in infantile hypotonia.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 12 , Issue 2 , May 1985 , pp. 111 - 120
Copyright
Copyright © Canadian Neurological Sciences Federation 1985

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