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Lewy Body Dementia Without Alzheimer Changes

Published online by Cambridge University Press:  18 September 2015

A.A.F. Sima ,
A.W. Clark ,
N.A. Sternberger  and
L.A. Sternberger
A.A.F. Sima*
Affiliation:
Section of Neuropathology, Department of Pathology, Health Sciences Centre, Winnipeg
A.W. Clark
Affiliation:
Department of Pathology, Foothills Hospital, Calgary
N.A. Sternberger
Affiliation:
Center for Brain Research, University of Rochester School of Medicine, Rochester, N.Y.
L.A. Sternberger
Affiliation:
Center for Brain Research, University of Rochester School of Medicine, Rochester, N.Y.
*
Health Sciences Centre, MS459A, 820 Sherbrook Street, Winnipeg, Manitoba, Canada R3A 1R9
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Abstract:

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Three patients with clinical Alzheimer's disease were found at postmortem examination to have Lewy-bodies and Lewy-like bodies in the cerebral cortex and the pigmented brainstem nuclei. Neuritic plaques were found in neocortical areas but no neurofibrillary tangles. The distribution of cortical neuronal inclusions correlated with the proposed projection of dopamine terminals. Neuronal cell loss was marked in the ventral tegmental area (paranigral nucleus) and the basal nucleus of Meynert, suggesting a defect in dopaminergic and cholinergic innervation of the cerebral cortex. Immunohistochemical investigations revealed positive staining of cortical Lewy- and Lewy-like bodies for monoclonal antibodies to phosphorylated neurofilaments (03-44, 06-17, 04-7). Also cerebral neurons containing no inclusions showed positivity, suggesting an early neurofilament abnormality, preceding the formation of Lewy-type inclusions.

Type
Cellular Clues to Pathogenesis
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue S4 , November 1986 , pp. 490 - 497
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

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