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Lipotropin, Melanotropin and Endorphin: In Vivo Catabolism and Entry into Cerebrospinal Fluid

Published online by Cambridge University Press:  18 September 2015

P.D. Pezalla ,
M. Lis ,
N.G. Seidah  and
M. Chrétien
P.D. Pezalla*
Affiliation:
Clinical Research Institute of Montreal, Affiliated to the Universite de Montréal and the Hôtel-Dieu de Montreal
M. Lis
Affiliation:
Clinical Research Institute of Montreal, Affiliated to the Universite de Montréal and the Hôtel-Dieu de Montreal
N.G. Seidah
Affiliation:
Clinical Research Institute of Montreal, Affiliated to the Universite de Montréal and the Hôtel-Dieu de Montreal
M. Chrétien
Affiliation:
Clinical Research Institute of Montreal, Affiliated to the Universite de Montréal and the Hôtel-Dieu de Montreal
*
Clinical Research Institute of Montreal, 110 avenue des Pins ouest, Montreal, Quebec H2W 1R7, Canada.
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Anesthetized rabbits were given intravenous injections of either beta-lipotropin (beta-LPH), betamelanotropin (beta-MSH) or betaendorphin. The postinjection concentrations of these peptides in plasma and cerebrospinal fluid (CSF) were measured by radioimmunoassay (RIA). The plasma disappearance half-times were 13.7 min for beta-LPH, 5.1 min for beta-MSH, and 4.8 min for beta-endorphin. Circulating beta-LPH is cleaved to peptides tentatively identified as gamma-LPH and beta-endorphin. Each of these peptides appeared in the CSF within 2 min postinjection. The maximum CSF to plasma ratios were 0.08 for beta-LPH, 1.48 for beta-MSH, and 0.23 for beta-endorphin.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 5 , Issue 2 , May 1978 , pp. 183 - 188
Copyright
Copyright © Canadian Neurological Sciences Federation 1978

References

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