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Long Term Induction of Kindled Seizures in Rats: Interhemispheric Factors

Published online by Cambridge University Press:  18 September 2015

José N. Nobrega  and
John Gaito
José N. Nobrega*
Affiliation:
Department of Psychology, York University
John Gaito
Affiliation:
Department of Psychology, York University
*
4700 Keele St., Downsview, Ontario, Canada M3J 1P3.
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Previous research indicated that sequential alternation of stimulation of certain homologous brain areas via chronically implanted electrodes resulted in oscillation of high and low latencies for convulsions. This phenomenon suggested the establishment of interhemispheric facilitatory-inhibitory effects as a result of repeated stimulation of the two brain sites. In the present study, the latency oscillation pattern was observed in split-brain rats as well as in bilaterally stimulated controls, but not in rats stimulated on one side only. Significant differences were observed between split-brain and control rats in terms of initial kindling rates, duration of convulsions and type of oscillation. Results are discussed in the context of possible interhemispheric mechanisms involved in long term kindling.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 5 , Issue 2 , May 1978 , pp. 223 - 230
Copyright
Copyright © Canadian Neurological Sciences Federation 1978

References

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