Hostname: page-component-6bf8c574d5-gr6zb Total loading time: 0 Render date: 2025-02-24T08:06:57.378Z Has data issue: false hasContentIssue false
  • English
  • Français

Lymphocytic Adenohypophysitis

Published online by Cambridge University Press:  18 September 2015

Michael W. McDermott ,
Donald E. Griesdale ,
Kenneth Berry  and
G. Edward Wilkins
Michael W. McDermott*
Affiliation:
Divisions of Neurosurgery, Neuropathology, and Endocrinology, University of British Columbia, Vancouver
Donald E. Griesdale
Affiliation:
Divisions of Neurosurgery, Neuropathology, and Endocrinology, University of British Columbia, Vancouver
Kenneth Berry
Affiliation:
Divisions of Neurosurgery, Neuropathology, and Endocrinology, University of British Columbia, Vancouver
G. Edward Wilkins
Affiliation:
Divisions of Neurosurgery, Neuropathology, and Endocrinology, University of British Columbia, Vancouver
*
Department of Surgery, 910 West 10th Avenue, Suite 3100, Vancouver, B.C., Canada V5Z 4E3
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Lymphocytic adenohypophysitis (LAH) is an uncommon disorder in the spectrum of pituitary disease. Twenty-three cases proven by biopsy or at autopsy have been reported since 1962. We report 2 further cases and review the etiology, immunology and pathology of the disease. The diagnosis should be considered in afemale patient who presents during the post-partum period with the clinical picture of a non-functional or prolactin cell pituitary adenoma and evidence of hypopituitarism.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 15 , Issue 1 , February 1988 , pp. 38 - 43
Copyright
Copyright © Canadian Neurological Sciences Federation 1988

References

REFERENCES

1.Botazzo, GF, Doniach, D. Pituitary auto immunity: A review. J R Soc Med 1978;71:433–436.CrossRefGoogle Scholar
2.Goudie, RB, Pinkerton, PH. Anterior hypophysitis and Hashimoto's disease in a young woman. J Path Bact 1962; 83: 584–585.CrossRefGoogle ScholarPubMed
3.Hume, R, Roberts, GH. Hypophysitis and hypopituitarism. Report of a case. Br Med J 1967; 2: 548–550.CrossRefGoogle ScholarPubMed
4.Madsen, FF, Dohr, O, Ludwigsen, E. Lymphocytic adenohypophysitis. A review and a case. Dan Med Bull 1985; 32: 185–188.Google ScholarPubMed
5.Meichner, RH, Riggio, S, et al. Lymphocytic adenohypophysitis causing a pituitary mass. Neurology 1987; 37: 158–161.CrossRefGoogle ScholarPubMed
6.Pouplard, A. Pituitary auto-immunity. Horm Res 1982; 16: 289–297.CrossRefGoogle Scholar
7.Topliss, DJ, Volpe, R. Lymphocytic hypophysitis (editorial). Ann Intern Med 1981;95:227–229.CrossRefGoogle Scholar
8.Barkan, AL, Kelch, RP, Marshall, JC. Isolated gonadotrope failure in the polyglandular auto immune syndrome. N Engl J Med 1985; 312: 1535–1540.Google Scholar
9.Loriaux, DL. The polyendocrine deficiency syndromes (editorial): N Engl J Med 1985; 312: 1568–1569.CrossRefGoogle Scholar
10.Botazzo, GF, Mcintosh, C, Stanford, W, et al. Growth hormone cell antibodies and partial growth hormone deficiency in a girl with Turner’s syndrome. Clin Endocrinol 1980; 12: 1–9.CrossRefGoogle Scholar
11.Botazzo, GF, Pouplard, A, Florin-Christiansen, A, et al. Auto antibodies of prolactin secreting cells of human pituitary. Lancet 1975; 19: 97–101.CrossRefGoogle Scholar
12.Engelberth, O, Jezkova, Z. Auto antibodies in Sheehan's syndrome. Lancet 1965; 1: 1075.CrossRefGoogle Scholar
13.Klein, I, Kraus, KE, Martines, AJ, et al. Evidence of cellular immunity in an animal model of auto-immune pituitary disease. Endocr Res Commun Comm 1982; 9: 145–153.CrossRefGoogle Scholar
14.Levine, S. Allergic adenohypophysitis. New experimental disease of the pituitary gland. Science 1967; 158: 1190–1191.CrossRefGoogle ScholarPubMed
15.Asa, SL, Bilbao, JM, Kovacs, Ketal. Lymphocytic hypophysitis of pregnancy resulting in hypopituitarism: A distinct clinical pathological entity. Ann Intern Med 1981; 95: 166–171.CrossRefGoogle Scholar
16.Baskin, BS, Townsend, JJ, Wilson, CB. Lymphocytic adenohypophysitis of pregnancy simulating a pituitary adenoma: A distinct pathologic entity. J Neurosurg 1982; 56: 148–153.CrossRefGoogle Scholar
17.Cebelin, MS, Velasco, ME, De las Mulas, JM, et al. Galactoria associated with lymphocytic adenohypophysitis. Case report. Br J Obstet Gynaecol 1981; 88: 675–680.CrossRefGoogle ScholarPubMed
18.Egloff, B, Fischbacher, w, Von Goumoens, E. Lymphomatose hypophysitis mit hypophyseninsuffizienz. Schweiz Med Wschr 1969; 99: 1499–1502.Google Scholar
19.Gleason, TH, Stebbins, PL, Shanahan, MF. Lymphoid hypophysitis in a patient with hypoglycemic episodes. Arch Pathol Lab Med 1978; 102: 46–48.Google Scholar
20.Hungerford, GD, Biggs, PJ, Levine, GH, et al. Lymphoid adenohypophysitis with radiologic and clinical findings resembling a pituitary tumour. AJNR 1982; 3: 444–446.Google Scholar
21.Jensen, MD, Handwerger, BS, et al. Lymphocytic hypophysitis with isolated corticotropin deficiency. Ann Intern Med 1986; 105: 200–203.CrossRefGoogle ScholarPubMed
22.Kurisaka, M, Kamimura, Y, et al. Lymphocytic adenohyphysitis. Case report. Neurol Med Chir (Tokyo) 1986; 26: 167–172.CrossRefGoogle ScholarPubMed
23.Lack, EE. Lymphoid hypophysitis with end organ insufficiency. Arch Pathol 1975; 99: 215–219.Google ScholarPubMed
24.Ludwig, H, Schernthaner, G. Multi-organs specific auto immunity in idiopathic adrenal insufficiency. Wiener Klinische Wochen-scherift 1978; 90: 736–741.Google Scholar
25.Madsen, FF, Dohr, O, Ludwigsen, E. Lymphocytic adenohypophysitis. A review and a case. Dan Med Bull 1985; 32: 185–188.Google ScholarPubMed
26.Mayfield, RK, Levine, JH, Gordon, L, et al. Lymphoid adenohypophysitis presenting as a pituitary tumour. Am J Med 1980; 69: 619–623.Google Scholar
27.Mazzone, P, Kelly, W, Ensinck, J. Lymphocytic hypophysitis associ-ated with anti-parietal cell antibodies and vitamin B12 deficiency. Arch Intern Med 1983; 1794–1795.CrossRefGoogle Scholar
28. Portocarrero, CJ, Robinson, AG, Taylor, L, et al. Lymphoid hypophysitis. An unusual case of hyperprolactinemia, and enlarged sella turcica. JAMA 1981; 246: 1811–1812.CrossRefGoogle ScholarPubMed
29.Quencer, RM. Lymphocytic adenohypophysitis. Auto immune disorder of the pituitary gland. AJNR 1980; 1: 343–345.Google Scholar
30.Richtsmeier, AJ, Henry, RA, Bloodworth, JMB, et al. Lymphocytic hypophysitis with selective adrenal corticotropic hormone deficiency. Arch Intern Med 1980; 140: 1243–1245.CrossRefGoogle ScholarPubMed
31.Sobrinho-Simoes, M, Brandao, A, Paiva, ME, et al. Lymphoid hypophysitis in a patient with lymphoid thyroiditis, lymphoid adrenolytis and idiopathic retroperitoneal fibrosis. Arch Pathol Lab Med 1985; 109: 230–233.Google Scholar
32. Wild, RA, Kepley, M. Lymphocytic hypophysitis in a patient with amenorrhea and hyperprolactinemia. A case report. J Reprod Med 1986; 31: 211–216.Google Scholar
33.Shanklin, WM. Lymphocytes and lymphoid tissue in the human pituitary. Anat Ree 1951; 111: 177–185.CrossRefGoogle ScholarPubMed
34.Burke, CW, Moore, RA, Rees, LH, et al. Isolated ACTH deficiency and TSH deficiency in the adult. J R Soc Med 1979; 72: 328–335.CrossRefGoogle ScholarPubMed
35.Gossain, VV, Robner, DR. Primary hypoathyroidism, pituitary insufficiency and pregnancy. A case report. J Reprod Med 1984; 29: 284–288.Google ScholarPubMed
36.Notterman, RB, Jovanovic, L, Peterson, R, et al. Spontaneous hypoglycemic seizures in pregnancy. A manifestation of panhypopituitarism. Arch Intern Med 1984; 144: 189–191.CrossRefGoogle ScholarPubMed
37.Pouplard-Barthelaix, A, Lepinard, V, Luxembourger, L, et al. Circulating pituitary auto antibodies against cells secreting luteinizing and follicle stimulating hormones in children with cryptorchidism (letter). Lancet 1984; 15: 631–632.CrossRefGoogle Scholar
38.Zellar, JR, Cerletty, JM, Rabinovitch, RA, et al. Spontaneous regression of a post partum pituitary mass demonstrated by computed tomography. Arch Int Med 1982; 142: 373.CrossRefGoogle Scholar
39.Triplett, EL. On the mechanism of immunologic self recognition. J Immunol 1962; 89: 505–10.CrossRefGoogle ScholarPubMed
40.Arvanitakis, C, Knouss, RF. Selective hypopituitarism. Impaired cell mediated immunity and chronic mucocutaneous candidasis. JAMA 1973; 225: 1492–1495.CrossRefGoogle Scholar
41.Haspel, MV, Ondera, T, Prabhakar, BS, et al. Virus-induced auto immunity: Monoclonal antibodies that react with endocrine tissues (abstract). Science 1983; 220: 304–306.CrossRefGoogle Scholar
42.Mirakian, R, Cudworth, AJ, Botazzo, GF, et al. Auto immunity to anti-pituitary cells and the pathogenesis of insulin-dependent diabetes mellitus. Lancet 1982; 1: 755–759.CrossRefGoogle Scholar
43.Onodera, T, Toniolo, A, Ray, UR, et al. Virus induced diabetes mellitus. Polyendocrinopathy and autoimmunity. J Exp Med 1981; 153: 1457–1473.CrossRefGoogle ScholarPubMed
44.Satoh, J, Prabhakar, BS, Haspel, MV, et al. Human monoclonal antibody that react with multiple endocrine organs. N Engl J Med 1983; 309: 217–220.CrossRefGoogle ScholarPubMed
45.Froelich, CJ, Goodman, JS, Bankhurst, AP, et al. Pregnancy, a temporary fetal graft of suppressor cells in auto immune disease? Am J Med 1980; 69: 329–331.Google Scholar
46.Pitkin, RM. Auto immune diseases in pregnancy. Semin Perinatol 1977; 1: 161–168.Google Scholar
47.Ludmerer, KM, Kissane, JM. CPC: Primary hypothyroidism and hypopituitarism in a young woman. Am J Med 1984; 77:319–330.Google Scholar