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Measurement of Ataxia and Related Neurological Signs in the Laboratory Rat

Published online by Cambridge University Press:  18 September 2015

F.B. Jolicoeur ,
D.B. Rondeau ,
E. Hamel ,
R. F. Butterworth  and
A. Barbeau
F.B. Jolicoeur
Affiliation:
The Clinical Research Institute of Montreal
D.B. Rondeau
Affiliation:
The Clinical Research Institute of Montreal
E. Hamel
Affiliation:
The Clinical Research Institute of Montreal
R. F. Butterworth
Affiliation:
The Clinical Research Institute of Montreal
A. Barbeau
Affiliation:
The Clinical Research Institute of Montreal
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Summary

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The purpose of the present study was to design a standard battery of tests capable of quantitatively characterizing ataxia and concomitant neurological signs in the rat. In addition to a systematic analysis of the walking gait of animals, tests for activity, catalepsy, rigidity, and various reflexive responses were included in the battery. The standardization and validation of the test system was performed by determining and comparing profiles of neurobehavioral effects produced by 3-acetyl pyridine, acrylamide, pyrithiamine, and thiamine deficiency, four experimental treatments reported to induce ataxia in animals. Results indicate that profiles of neurobehavioral disturbances accompanying ataxia in animals varied distinctively with each experimental treatment.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 6 , Issue 2 , May 1979 , pp. 209 - 215
Copyright
Copyright © Canadian Neurological Sciences Federation 1979

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