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Morphological Responses of Cerebral Tissues to Temporary Ischemia

Published online by Cambridge University Press:  18 September 2015

Ronald F. Dodson ,
Yukio Tagashira ,
Yasuo Kawamura  and
Lena Wai-Fong Chu
Ronald F. Dodson*
Affiliation:
Departments of Neurology and Pathology, Baylor College of Medicine and the Baylor-Methodist Center for Cerebrovascular Research, Houston, Texas 77025
Yukio Tagashira
Affiliation:
Departments of Neurology and Pathology, Baylor College of Medicine and the Baylor-Methodist Center for Cerebrovascular Research, Houston, Texas 77025
Yasuo Kawamura
Affiliation:
Departments of Neurology and Pathology, Baylor College of Medicine and the Baylor-Methodist Center for Cerebrovascular Research, Houston, Texas 77025
Lena Wai-Fong Chu
Affiliation:
Departments of Neurology and Pathology, Baylor College of Medicine and the Baylor-Methodist Center for Cerebrovascular Research, Houston, Texas 77025
*
Department of Neurology, Baylor College of Medicine, 1200 Moursund Avenue, Houston, Texas 77025
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Summary:

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The ultrastructural responses of cerebral tissue following temporary periods (½, 1, 2, 3, or 4 hour) of right, middle cerebral artery, (MCA) occlusion were studied acutely after a 3 day or 7 day interval following the removal of the MCA clip. Cortical and basal ganglia tissues for each ischemic duration were compared at 3 post-occlusive periods (acute, 3 days, 7 days).

With the short periods of ischemic insult (½, 1, 2, 3, and 4 hour), the temporal and insular cortex contained no greater changes in the 7 day group than in the 3 day group.

The basal ganglia were more susceptible to MCA occlusion as indicated by more marked cytological changes and/or necrosis in all intervals of ischemia.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 2 , Issue 3 , August 1975 , pp. 173 - 177
Copyright
Copyright © Canadian Neurological Sciences Federation 1975

References

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