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Neuroblastoma and Fetal Exposure to Phenytoin in a Child Without Dysmorphic Features

Published online by Cambridge University Press:  18 September 2015

S. Al-Shammri ,
A. Guberman  and
E. Hsu
S. Al-Shammri
Affiliation:
Division of Neurology, Ottawa General Hospital
A. Guberman*
Affiliation:
Division of Neurology, Ottawa General Hospital
E. Hsu
Affiliation:
Department of Pediatrics, Children’s Hospital of Eastern Ontario
*
Division of Neurology, Ottawa General Hospital, 501 Smyth Road, Ottawa, Ontario, Canada KIH 8L6
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Abstract:

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Despite the fact that the teratogenic effects of phenytoin have been suggested in several case reports, the evidence for a possible oncogenic potential of phenytoin has not been widely recognized. Recently, neuroblastoma as well as other neuroectodermal and non-ectodermal tumors has been seen in several children exposed to phenytoin prenatally. Previous cases have been almost uniformly associated with the features of “fetal hydantoin syndrome” and none have been developmentally normal. We report a developmentally-normal boy of 2½ years with an abdominal neuroblastoma whose mother had been on phenytoin (as well as carbamazepine) throughout gestation. We review the various neoplasms which have been reported in the offspring of mothers receiving phenytoin.

Type
Articles
Information
Canadian Journal of Neurological Sciences , Volume 19 , Issue 2 , May 1992 , pp. 243 - 245
Copyright
Copyright © Canadian Neurological Sciences Federation 1992

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