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Neurologic Disorders Associated with Mitral Valve Prolapse

Published online by Cambridge University Press:  18 September 2015

Alan C. Jackson
Alan C. Jackson*
Affiliation:
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland
*
Department of Neurology, Johns Hopkins University, 600 N. Wolfe St./Meyer 6-181, Baltimore, Maryland, U.S.A. 21205
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Abstract:

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Mitral valve prolapse has been reported to be associated with a variety of neurologic disorders, including cerebral ischemia, transient global amnesia, migraine, autonomic dysfunction, and psychiatric disease. The evidence supporting these associations and possible pathogenetic mechanisms are discussed. Some neurologic disorders may be direct complications of mitral valve prolapse, while others may occur as part of an underlying genetic defect or common link.

Type
Special Features
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue 1 , February 1986 , pp. 15 - 20
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

References

REFERENCES

1.Cheitlin, MD, Byrd, RC.Prolapsed mitral valve: the commonest valve disease? Curr Probl Cardiol 1984; 8: 1–54.CrossRefGoogle ScholarPubMed
2.Devereux, RB, Perloff, JK, Reichek, Net al. Mitral valve prolapse. Circulation 1976; 54: 3–14.CrossRefGoogle ScholarPubMed
3.Gravanis, MB, Campbell, WB.The syndrome of prolapse of the mitral valve, an etiologic and pathogenic enigma. Arch Pathol Lab Med 1982; 106: 369–374.Google ScholarPubMed
4.Wigle, ED, Rakowski, H, Ranganathan, Net al. Mitral valve prolapse. Annu Rev Med 1976; 27: 165–180.CrossRefGoogle ScholarPubMed
5.Morganroth, J, Mardelli, TJ, Naito, Met al. Apical cross-sectional echocardiography, standard for the diagnosis of idiopathic mitral valve prolapse syndrome. Chest 1981; 79: 23–28.CrossRefGoogle ScholarPubMed
6.Lucas, RV, Edwards, JE.The floppy mitral valve. Curr Probl Cardiol 1982; 7: 1–48.CrossRefGoogle ScholarPubMed
7.Cole, WG, Chan, D, Hickey, AJet al. Collagen composition of normal and myxomatous human mitral heart valves. Biochem J 1984; 219: 451–460.CrossRefGoogle ScholarPubMed
8.Hammer, D, Leier, CV, Baba, Net al. Altered collagen composition in a prolapsing mitral valve with ruptured chordae tendineae. Am J Med 1979; 67: 863–866.CrossRefGoogle Scholar
9.Davies, MJ, Moore, BP, Braimbridge, MV.The floppy mitral valve, study of incidence, pathology, and complications in surgical, necropsy, and forensic material. Br Heart J 1978; 40: 468–481.CrossRefGoogle ScholarPubMed
10.Savage, DD, Garrison, RJ, Devereux, RBet al. Mitral valve prolapse in the general population. I. Epidemiologic features: the Fra-mingham study. Am Heart J 1983; 106: 571–576.CrossRefGoogle ScholarPubMed
11.Barnett, HJM.Transient cerebral ischemia, pathogenesis, prognosis and management. Ann R Coll Physicians Surg Can 1974; 7: 153–173.Google Scholar
12.Barnett, HJM, Jones, MW, Boughner, DRet al. Cerebral ischemic events associated with prolapsing mitral valve. Arch Neurol 1976; 33: 777–782.CrossRefGoogle ScholarPubMed
13.Barlow, JB, Bosnian, CK.Aneurysmal protrusion of the posterior leaflet of the mitral valve, an auscultatory-electrocardiographic syndrome. Am Heart J 1966; 71: 166–178.CrossRefGoogle ScholarPubMed
14.Wilson, LA, Keeling, PWN, Malcolm, ADet al. Visual complications of mitral leaflet prolapse. Br Med J 1977; 2: 86–88.CrossRefGoogle ScholarPubMed
15.Barnett, HJM, Boughner, DR, Taylor, DWet al. Further evidence relating mitral-valve prolapse to cerebral ischemic events. N Engl J Med 1980; 302: 139–144.CrossRefGoogle ScholarPubMed
16.Scharf, RE, Hennerici, M, Bluschke, Vet al. Cerebral ischemia in young patients: is it associated with mitral valve prolapse and abnormal platelet activity in vivo? Stroke 1982; 13: 454–458.CrossRefGoogle ScholarPubMed
17.Egeblad, H, Sorensen, PS.Prevalence of mitral valve prolapse in younger patients with cerebral ischaemic attacks. Acta Med Scand 1984; 216: 385–391.CrossRefGoogle ScholarPubMed
18.De Bono, DP, Warlow, CP.Potential sources of emboli in patients with presumed transient cerebral or retinal ischemia. Lancet 1981; 1: 343–345.CrossRefGoogle ScholarPubMed
19.Bensaid, J, Cuisinier, Y,Renaudin, Det al. Accidents vasculaires cérébraux ischemiques: role etiologique du prolapus valulaire mitral. Nouv Presse Med 1980; 9: 1716.Google Scholar
20.Fieschi, C, Francia, A, Allori, Let al. Mitral valve prolapse as a risk factor for TIA, a study with echocardiography and dynamic ECG. Eur Neurol 1983; 22: 233–239.CrossRefGoogle Scholar
21.Kouvaras, G, Bacoulas, G.Association of mitral valve prolapse with cerebral ischaemic events in the young and early middle-aged patient. Q J Med 1985; 55: 387–392.Google Scholar
22.Tharakan, J, Ahuja, GK, Manchanda, SCet al. Mitral valve prolapse and cerebrovascular accidents in the young. Acta Neurol Scand 1982; 66: 295–302.CrossRefGoogle ScholarPubMed
23.Greenland, P, Knopman, DS, Mikell, FLet al. Echocardiography in diagnostic assessment of stroke. Ann Intern Med 1981; 95:51–53.CrossRefGoogle ScholarPubMed
24.Smith, DL, McKnight, TE.TIAs, completed strokes, and mitral valve prolapse. South Med J 1981; 74: 1454–1456.CrossRefGoogle ScholarPubMed
25.Gagliardi, R, Benvenuti, L, Frosini, Fet al. Frequency of echocardiographic abnormalities in patients with ischemia of the carotid territory-a preliminary report. Stroke 1985; 16: 118–120.CrossRefGoogle ScholarPubMed
26.Sandok, BA, Giuliani, ER.Cerebral ischemic events in patients with mitral valve prolapse. Stroke 1982; 13: 448–450.CrossRefGoogle ScholarPubMed
27.Barnett, HJM.Cardiac causes of cerebral ischemia. In: Toole, JF, ed. Cerebrovascular Disorders. 3rd edition. New York: Raven Press, 1984: pp 174–177.Google Scholar
28.Caltrider, ND, Irvine, AR, Kline, HJet al. Retinal emboli in patients with mitral valve prolapse. Am J Ophthalmol 1980; 90: 534–539.CrossRefGoogle ScholarPubMed
29.Pomerance, A.Ballooning deformity (mucoid degeneration) of atrioventricular valves. Br Heart J 1969; 31: 343–351.CrossRefGoogle ScholarPubMed
30.Chesler, E, King, RA, Edwards, JE.The myxomatous mitral valve and sudden death. Circulation 1983; 67: 632–639.CrossRefGoogle ScholarPubMed
31.Donaldson, RM, Emanuel, RW, Earl, CJ.The role of two-dimensional echocardiography in the detection of potentially embolic intra cardiac masses in patients with cerebral ischaemia. J Neurol Neurosurg Psychiatry 1981; 44: 803–809.CrossRefGoogle Scholar
32.Bramlet, DA, Decker, EL, Floyd, WL.Nonbacterial thrombotic endocarditis as a cause of stroke in mitral valve prolapse. South Med J 1982; 75: 1133–1135.CrossRefGoogle ScholarPubMed
33.Cook, AW, Bird, TD, Spence, AMet al. Myotonic dystrophy, mitral-valve prolapse, and stroke (letter). Lancet 1978; 1:335–336.CrossRefGoogle Scholar
34.Geyer, SJ, Franzini, DA.Myxomatous degeneration of the mitral valve complicated by nonbacterial thrombotic endocarditis with systemic embolization. Am J Clin Pathol 1979; 72: 489–492.CrossRefGoogle ScholarPubMed
35.Schnee, MA, Bucal, AA.Fatal embolism in mitral valve prolapse. Chest 1983; 83: 285–287.CrossRefGoogle ScholarPubMed
36.Hart, RG, Easton, JD.Mitral valve prolapse and cerebral infarction. Stroke 1982; 13: 429–430.CrossRefGoogle ScholarPubMed
37.Barletta, GA, Gagliardi, R, Benvenuti, Let al. Cerebral ischemic attacks as a complication of aortic and mitral valve prolapse. Stroke 1985; 16: 219–223.CrossRefGoogle ScholarPubMed
38.Zenker, G, Bone, G, Ladurner, Get al. The myxomatous mitral valve, a risk factor for ischemic stroke in young patients? Eur Neurol 1985; 24: 82–84.CrossRefGoogle ScholarPubMed
39.Jackson, AC, Boughner, DR, Barnett, HJM.Mitral valve prolapse and cerebral ischemic events in young patients. Neurology (Cleveland) 1984; 34: 784–787.CrossRefGoogle ScholarPubMed
40.Barnett, HJM.Embolism in mitral valve prolapse. Annu Rev Med 1982; 33: 489–507.CrossRefGoogle ScholarPubMed
41.Devereux, RB, Brown, WT. Genetics of mitral valve prolapse. Prog Med Genet 1983; 5: 139–161.Google ScholarPubMed
42.Rice, GPA, Boughner, DR, Stiller, Cet al. Familial stroke syndrome associated with mitral valve prolapse. Ann Neur 1980; 7: 130–134.CrossRefGoogle ScholarPubMed
43.Fisher, M, Budnitz, E.Focal cerebral ischemia and mitral valve prolapse in monozygotic twins. Arch Intern Med 1983; 143:2180–2181.CrossRefGoogle ScholarPubMed
44.Fisher, CM, Adams, RD.Transient global amnesia syndrome. Acta Neurol Scand 1964; 40(Suppl 9): 7–82.Google Scholar
45.Logan, W, Sherman, DG.Transient global amnesia. Stroke 1983; 14: 1005–1007.CrossRefGoogle ScholarPubMed
46.Shuping, JR, Rollison, RD, Toole, JF.Transient global amnesia. Ann Neurol 1980; 7: 281–285.CrossRefGoogle ScholarPubMed
47.Jackson, AC, Boughner, DR, Bolton, CFet al. Transient global amnesia associated with mitral valve prolapse (abstract). Neurology 1985; 35 (Suppl 1): 215.Google Scholar
48.Pruitt, A, Rubin, RH, Karchmer, AWet al. Neurologic complications of bacterial endocarditis. Medicine (Baltimore) 1978; 57: 329–343.CrossRefGoogle ScholarPubMed
49.Corrigall, D, Bolen, J, Hancock, EWet al. Mitral valve prolapse and infective endocarditis. Am J Med 1977; 63: 215–222.CrossRefGoogle ScholarPubMed
50.Hanson, M, Conomy, JP, Capraro, J.Mitral valve prolapse, cerebral ischemia, and bacterial endocarditis (abstract). Neurology 1982; 32 (Suppl 2): A88.Google Scholar
51.Litman, GI, Friedman, HM.Migraine and the mitral valve prolapse syndrome. Am Heart J 1978; 96: 610–614.CrossRefGoogle ScholarPubMed
52.Amat, G, Louis, PJ, Loisy, Cet al. Migraine and the mitral valve prolapse syndrome. Adv Neurol 1982; 33: 27–29.Google ScholarPubMed
53.Gamberini, G, D’Alessandro, R, Labriola, Eet al. Further evidence on the association of mitral valve prolapse and migraine. Headache 1984; 24: 39–40.CrossRefGoogle ScholarPubMed
54.Spence, JD, Wong, DG, Melendez, LJet al. Increased prevalence of mitral valve prolapse in patients with migraine. Can Med Assoc J 1984; 131: 1457–1460.Google ScholarPubMed
55.Deshmukh, SV, Meyer, JS.Cyclic changes in platelet dynamics and the pathogenesis and prophylaxis of migraine. Headache 1977; 17: 101–108.CrossRefGoogle ScholarPubMed
56.Gawel, M, Burkitt, M, Rose, FC.The platelet release reaction during migraine attacks. Headache 1979; 19: 323–327.CrossRefGoogle ScholarPubMed
57.Jackson, AC.Association of mitral valve prolapse and intracranial aneurysms. South Med J 1983; 76: 712–713.CrossRefGoogle ScholarPubMed
58.Neil-Dwyer, G, Bartlett, JR, Nicholls, ACet al. Collagen deficiency and ruptured cerebral aneurysms: a clinical and biochemical study. J Neurosurg 1983; 59: 16–20.CrossRefGoogle ScholarPubMed
59.Lippman, SM, Abergel, RP, Ginzton, LEet al. Mitral valve prolapse in sickle cell disease: manifestation of a generalized connective tissue disorder. Am J Hematol 1985; 19: 1–12.CrossRefGoogle ScholarPubMed
60.Lippman, SM, Ginzton, LE, Thigpen, T.et al. Mitral valve prolapse in sickle cell disease, presumptive evidence fora linked connective tissue disorder. Arch Intern Med 1985; 145: 435–438.CrossRefGoogle Scholar
61.Pickering, NJ, Brody, JI, Barrett, MJ.Von Willebrand syndromes and mitral-valve prolapse, linked mesenchymal dysplasia. N Engl J Med 1981; 305: 131–134.CrossRefGoogle Scholar
62.Andrews, RJ.Collagen in cerebral aneurysms, mitral valve prolapse, and von Willebrand syndrome (letter). Stroke 1984; 15: 917.CrossRefGoogle Scholar
63.Hanson, MR, Conomy, JP, Hodgman, JR.Brain events associated with mitral valve prolapse. Stroke 1980; 11: 499–506.CrossRefGoogle ScholarPubMed
64.Smirniotopoulos, TT, Sheppard, GL.Mitral-valve prolapse presenting with seizures: case report. Va Med 1984; 111: 699–700.Google ScholarPubMed
65.Taylor, D, Horenstein, S, Williams, Get al. Syncope, seizure, and stroke in the mitral valve prolapse syndrome. Trans Am Neurol Assoc 1979; 104: 114–116.Google ScholarPubMed
66.Winters, SJ, Schreiner, B, Griggs, RCet al. Familial mitral valve prolapse and myotonic dystrophy. Ann Intern Med 1976; 85:19–22.CrossRefGoogle ScholarPubMed
67.Morris, LK, Cuetter, AC, Gunderson, CH.Myotonic dystrophy, mitral valve prolapse, and cerebral embolism. Stroke 1982; 13: 93–94.CrossRefGoogle ScholarPubMed
68.Biddison, JH, Dembo, DH, Spalt, Het al. Familial occurrence of mitral valve prolapse in X-linked muscular dystrophy. Circulation 1979; 59: 1299–1304.CrossRefGoogle ScholarPubMed
69.Reeves, W, Griggs, R, Nanda, NCet al. Echocardiographic demonstration of mitral valve prolapse in muscular dystrophy (abstract). Circulation 1976; 54 (Suppl 2): 97.Google Scholar
70.Sanyal, SK, Leung, RKF, Tierney, RCet al. Mitral valve prolapse syndrome in children with Duchenne’s progressive muscular dystrophy. Pediatrics 1979; 63: 116–123.CrossRefGoogle ScholarPubMed
71.Arocha, F, Diez-Ewald, M, Durango, AIet al. Platelet activity in mitral valve prolapse: a study of platelet aggregation, malondial-dehyde production, and plasma β-thromboglobulin. Am J Hematol 1985; 19: 21–25.CrossRefGoogle Scholar
72.Fisher, M, Weiner, B, Ockene, ISet al. Platelet activation and mitral valve prolapse. Neurology (Cleveland) 1983; 33: 384–386.CrossRefGoogle ScholarPubMed
73.Steele, P, Weily, H, Rainwater, Jet al. Platelet survival time and thromboembolism in patients with mitral valve prolapse. Circulation 1979; 60: 43–45.CrossRefGoogle ScholarPubMed
74.Walsh, PN, Kansu, TA, Corbett, JJet al. Platelets, thromboembolism and mitral valve prolapse. Circulation 1981; 63: 552–559.CrossRefGoogle ScholarPubMed
75.Wooley, CF.Where are the diseases of yesteryear? DaCosta’s syndrome, soldiers heart, the effort syndrome, neurocirculatory asthenia-and the mitral valve prolapse syndrome. Circulation 1976; 53: 749–751.CrossRefGoogle ScholarPubMed
76.Boudoulas, H, Reynolds, JC, Mazzaferri, Eet al. Metabolic studies in mitral valve prolapse syndrome, a neuroendocrine-cardiovascular process. Circulation 1980; 61: 1200–1205.CrossRefGoogle ScholarPubMed
77.Boudoulas, H, Reynolds, JC, Mazzaferri, Eet al. Mitral valve prolapse syndrome: the effect of adrenergic stimulation. J Am Coll Cardiol 1983; 2: 638–644.CrossRefGoogle ScholarPubMed
78.Coghlan, HC, Phares, P, Cowley, Met al. Dysautonomia in mitral valve prolapse. Am J Med 1979; 67: 236–244.CrossRefGoogle ScholarPubMed
79.Gaffney, FA, Karlsson, ES, Campbell, Wet al. Autonomic dysfunction in women with mitral valve prolapse syndrome. Circulation 1979; 59: 894–901.CrossRefGoogle ScholarPubMed
80.Gaffney, FA, Bastian, BC, Lane, LBet al. Abnormal cardiovascular regulation in the mitral valve prolapse syndrome. Am J Cardiol 1983; 52: 316–320.CrossRefGoogle ScholarPubMed
81.Pasternac, A.Tubau, JF, Puddu, PEet al. Increased plasma catecholamine levels in patients with symptomatic mitral valve prolapse. Am J Med 1982; 73: 783–790.CrossRefGoogle ScholarPubMed
82.Chesler, E, Weir, EK, Braatz, GAet al. Normal catecholamine and hemodynamic responses to orthostatic tilt in subjects with mitral valve prolapse, correlation with psychologic testing. Am J Med 1985; 78: 754–760.CrossRefGoogle ScholarPubMed
83.Crowe, RR.Mitral valve prolapse and panic disorder. Psychiatry Clin North Am 1985; 8: 63–71.CrossRefGoogle ScholarPubMed
84.Klein, DF, Gorman, JM.Panic disorders and mitral valve prolapse. J Clin Psychiatry Monograph 1984; 2: 14–17.Google Scholar
85.Hickey, AJ, Andrews, G, Wilcken, DEL.Independence of mitral valve prolapse and neurosis. Br Heart J 1983; 50: 333–336.CrossRefGoogle ScholarPubMed
86.Kantor, JS, Zitrin, CM, Zeldis, SM.Mitral valve prolapse syndrome in agoraphobic patients. Am J Psychiatry 1980; 137: 467–469.Google ScholarPubMed
87.Clark, RW, Boudoulas, H, Schaal, SFet al. Adrenergic hyperactivity and cardiac abnormality in primary disorders of sleep. Neurology 1980; 30: 113–119.CrossRefGoogle ScholarPubMed
88.Barlow, JB, Pocock, WA.The mitral valve prolapse enigma-two decades later. Mod Concepts Cardiovasc Dis 1984; 53: 13–17.Google Scholar
89.Swartz, MH, Teichholz, LE, Donoso, E.Mitral valve prolapse, a review of associated arrhythmias. Am J Med 1977; 62: 377–389.CrossRefGoogle ScholarPubMed
90.Pocock, WA, Bosman, CK, Chesler, Eet al. Sudden death in primary mitral valve prolapse. Am Heart J 1984; 107: 378–382.CrossRefGoogle ScholarPubMed
91.Santos, AD, Mathew, PK, Hilal, Aet al. Orthostatic hypotension: a commonly unrecognized cause of symptoms in mitral valve prolapse. Am J Med 1981; 71: 746–750.CrossRefGoogle ScholarPubMed