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Non-Association of Friedreich's Ataxia and HLA Based on Five Families

Published online by Cambridge University Press:  18 September 2015

S. Chamberlain
Affiliation:
Friedreich's Ataxia Research Group and Department of Immunology, The London Hospital Medical College
J.L. Walker
Affiliation:
Friedreich's Ataxia Research Group and Department of Immunology, The London Hospital Medical College
J.A. Sachs*
Affiliation:
Friedreich's Ataxia Research Group and Department of Immunology, The London Hospital Medical College
J.A. Sachs*
Affiliation:
Friedreich's Ataxia Research Group and Department of Immunology, The London Hospital Medical College
E. Wolf
Affiliation:
Friedreich's Ataxia Research Group and Department of Immunology, The London Hospital Medical College
H. Festenstein
Affiliation:
Friedreich's Ataxia Research Group and Department of Immunology, The London Hospital Medical College
*
The London Hospital Medical College, Turner Street, London E1 2AD, England
The London Hospital Medical College, Turner Street, London E1 2AD, England
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Summary:

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HLA-A, B, and C typing was carried out on five families with classical Friedreich's Ataxia (F.A.). Segregation patterns in a total of 16 offspring. 10 with the disease and 6 without, indicated no association between F.A. and HLA.

Type
Research Article
Copyright
Copyright © Canadian Neurological Sciences Federation 1979

References

Geoffrey, F., Barbeau, A., Breton, G., Lemieux, B .Aube, M., Leger, C. and Bouchard, J.B. (1976) Clinical description and roenlgenic evaluation of patients with Friedreich–s Ataxia. Canadian Journal of Neurological Sciences 3: 279.CrossRefGoogle Scholar
Jackson, J.F., Currier, R.D.. Terasam, P.I. and Morton, E.N. (1977) Spinocerebellar Ataxia and HLA linkage. New Eng. J. Med. 296: 1138.CrossRefGoogle ScholarPubMed
Niese, D., Stroehmann, I. and Rittner, Ch. (1977) Association of Friedreich–s Ataxia with HLA-Bw35. Cw4 and Dwl. Tissue Antigens 10: 215.Google Scholar
Wastiaux, J.P., Lamoureux, G., Bouchard, J.P., Durivage, A., Barbeau, C. and Barbeau, A., (1977) HLA and complement typing in olivo-ponto cerebellar atrophy. Canadian Journal of Neurological Sciences 5: 75.CrossRefGoogle Scholar
Yakura, H., Wakisaka, A., Fujimoto, S.et al. (1974) Hereditary ataxia and HLA genotypes. New Eng. J. Med. 291: 154.Google Scholar