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Pallidotomy Increases Cortical Inhibition in Parkinson's Disease

Published online by Cambridge University Press:  18 September 2015

A. Strafella ,
P. Ashby ,
A. Lozano  and
A.E. Lang
A. Strafella
Affiliation:
Division of Neurology, Playfair Neuroscience Unit, University of Toronto; and the Morton and Gloria Shutman Movement Disorders Center, The Toronto Hospital, Toronto.
P. Ashby*
Affiliation:
Division of Neurology, Playfair Neuroscience Unit, University of Toronto; and the Morton and Gloria Shutman Movement Disorders Center, The Toronto Hospital, Toronto.
A. Lozano
Affiliation:
Division of Neurology, Playfair Neuroscience Unit, University of Toronto; and the Morton and Gloria Shutman Movement Disorders Center, The Toronto Hospital, Toronto.
A.E. Lang
Affiliation:
Division of Neurology, Playfair Neuroscience Unit, University of Toronto; and the Morton and Gloria Shutman Movement Disorders Center, The Toronto Hospital, Toronto.
*
The Toronto Hospital, Western Division, 8 EC-005, 399 Bathurst Street, Toronto, Ontario, Canada M5T 2S8
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Abstract:

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Background:

Pallidotomy helps parkinsonian symptoms. We tested the hypothesis that this might be due to changes in inhibition in the motor cortex.

Methods:

We examined 15 patients with parkinsonism before and after posteroventral pallidotomy. Magnetic stimuli were delivered over the motor cortex, while subjects maintained a 30% maximum voluntary contraction of the contralateral first dorsal interosseus (FDI).

Results:

Weak stimuli inhibited voluntary muscle activity, while slightly stronger stimuli caused short latency facilitation from activation of the corticospinal neurons. After pallidotomy magnetic stimulation, at the threshold for the short latency facilitation, resulted in more inhibition than before.

Conclusions:

Pallidotomy increases cortical inhibition. This may be associated with improved control of movements.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 24 , Issue 2 , May 1997 , pp. 133 - 136
Copyright
Copyright © Canadian Neurological Sciences Federation 1997

References

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