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Paraneoplastic Sensory Neuronopathy and Spontaneous Regression of Small Cell Lung Cancer

Published online by Cambridge University Press:  02 December 2014

Sharlene Gill ,
Nevin Murray ,
Josep Dalmau  and
Brian Thiessen
Sharlene Gill
Affiliation:
Division of Medical Oncology, British Columbia Cancer Agency, Vancouver BC
Nevin Murray
Affiliation:
Division of Medical Oncology, British Columbia Cancer Agency, Vancouver BC
Josep Dalmau
Affiliation:
Canada and Department of Neurology, University of Arkansas for Medical, Sciences, Little Rock, Arkansas, USA
Brian Thiessen
Affiliation:
Division of Medical Oncology, British Columbia Cancer Agency, Vancouver BC Division of Neurology, Vancouver General Hospital, Vancouver, BC
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Abstract

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Background:

Spontaneous tumour regression in small cell lung cancer has previously been suggested in patients with paraneoplastic neurologic syndromes. Rare documentation of this event has occurred in the literature.

Case Report:

The authors report a patient with anti-Hu associated paraneoplastic sensory neuronopathy who had a spontaneous regression of her small cell lung cancer.

Conclusions:

This case supports the hypothesis that anti-Hu neurologic syndromes are the consequence of a misdirected immune response to small cell tumours.

Résumé:

RÉSUMÉ: Introduction:

Une régression spontanée du cancer du poumon à petites cellules a déjà été observée chez des patients présentant des syndromes neurologiques paranéoplasiques. De rares cas ont été décrits dans la littérature.

Étude de cas:

Les auteurs rapportent le cas d’un patient présentant une neuropathie sensitive paranéoplasique avec anticorps anti-Hu chez qui un cancer du poumon à petites cellules a régressé spontanément.

Conclusions:

Ce cas appuie l’hypothèse selon laquelle les syndromes neurologiques anti-Hu sont la conséquence d’une réponse immunitaire aberrante à des tumeurs à petites cellules.

Type
Case Report
Information
Canadian Journal of Neurological Sciences , Volume 30 , Issue 3 , August 2003 , pp. 269 - 271
Copyright
Copyright © The Canadian Journal of Neurological 2003

References

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