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PET Studies of Parkinsonian Patients Treated with Autologous Adrenal Implants

Published online by Cambridge University Press:  18 September 2015

M. Guttman ,
R.S. Burns ,
W.R.W. Martin ,
R.F. Peppard ,
M.J. Adam ,
T.J. Ruth ,
G. Allen ,
R.A. Parker ,
N.B. Tulipan  and
D.B. Calne
M. Guttman*
Affiliation:
UBC/TRIUMF PET Group, and the Division of Neurology, Department of Medicine, University of British Columbia, Vancouver
R.S. Burns
Affiliation:
Department of Neurosurgery and Neurology, Vanderbilt University, Nashville, Tennessee
W.R.W. Martin
Affiliation:
UBC/TRIUMF PET Group, and the Division of Neurology, Department of Medicine, University of British Columbia, Vancouver
R.F. Peppard
Affiliation:
UBC/TRIUMF PET Group, and the Division of Neurology, Department of Medicine, University of British Columbia, Vancouver
M.J. Adam
Affiliation:
UBC/TRIUMF PET Group, and the Division of Neurology, Department of Medicine, University of British Columbia, Vancouver
T.J. Ruth
Affiliation:
UBC/TRIUMF PET Group, and the Division of Neurology, Department of Medicine, University of British Columbia, Vancouver
G. Allen
Affiliation:
Department of Neurosurgery and Neurology, Vanderbilt University, Nashville, Tennessee
R.A. Parker
Affiliation:
Department of Neurosurgery and Neurology, Vanderbilt University, Nashville, Tennessee
N.B. Tulipan
Affiliation:
Department of Neurosurgery and Neurology, Vanderbilt University, Nashville, Tennessee
D.B. Calne
Affiliation:
UBC/TRIUMF PET Group, and the Division of Neurology, Department of Medicine, University of British Columbia, Vancouver
*
3801 University, Montreal, Quebec, Canada H3A 2B4
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Abstract:

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Transplantation of autologous adrenal medulla tissue into the striatum has recently been proposed as a treatment for Parkinson's disease. We report the use of positron emission tomography (PET) to evaluate patients who had adrenal implants placed into the right caudate. 6-[18F] fluoro-L-dopa (6-FD) scans were performed to study the integrity and activity of the implant, and the nigrostriatal dopamine system before and six weeks after transplantation surgery. [68Ga] Gallium-ethylenediaminetetraacetate (Ga) scans were also performed to assess the blood brain barrier. The Ga scans performed on two patients showed increased permeability of the blood brain barrier at the surgical site. 6-FD PET scans in five patients did not show a consistent change in striatal uptake following adrenal medullary implantation after six weeks. Further assessment of implant viability with 6-FD PET scans after longer follow up may provide useful information if the blood-brain barrier becomes re-established with the passage of time.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 16 , Issue 3 , August 1989 , pp. 305 - 309
Copyright
Copyright © Canadian Neurological Sciences Federation 1989

References

REFERENCES

1.Perlow, MJ. Brain grafting as a treatment for Parkinson’s disease. Neurosurg 1987; 20: 335–342.CrossRefGoogle ScholarPubMed
2.Madrazo, I, Drucker-Colin, R, Diaz, V, et al. Open microsurgical autograft of adrenal medulla to the right caudate nucleus in two patients with intractable Parkinson’s disease. N Engl J Med 1987; 316: 831–834.CrossRefGoogle Scholar
3.Olanow, CW, Cahill, D, Cox, C. Autologous transplantation of adrenal medulla to caudate nucleus in Parkinson’s disease. Neurology 1988; 38 (Suppl 1): 142.Google Scholar
4.Lieberman, AN, Ransohoff, J, Koslow, M. Adrenal medullary to caudate nucleus transplant as an effective treatment for advanced Parkinson’s disease (PD). Neurology 1988; 38 (Suppl 1): 142.Google Scholar
5.Goetz, CG, Tanner, CM, Penn, RD, et al. Efficacy of intrastriatal adrenal medulla transplant in Parkinson’s disease. Neurology 1988; 38 (Suppl 1): 142–143.Google Scholar
6.Watts, RL, Bakay, RAE, Iuvone, PM, et al.Autologous adrenalcaudate transplantation in patients with Parkinson’s disease (PD). Neurology 1988; 38 (Suppl 1): 143.Google Scholar
7.Allen, GS, Burns, RS, Tulipan, NB, Parker, RA. Adrenal medullary transplantation to caudate nucleus in Parkinson’s disease: Initial clinical results in eighteen patients. Arch Neurol 1989 (in press).CrossRefGoogle Scholar
8.Lindvall, O, Backlund, E-O, Farde, L, et al. Transplantation in Parkinson’s disease: Two cases of adrenal medullary grafts to the putamen. Ann Neurol 1987; 22: 457–468.CrossRefGoogle ScholarPubMed
9.Tinter, R, Clark, K, Horn, J, et al. Adrenomedullary transplantation in Parkinson’s disease: Quantitative neurologic and biochemical investigation.Neurology 1988; 38 (Suppl 1): 143.Google Scholar
10.Carvey, PM, Kroin, JS, Zhang, TJ, et al. Biochemical and immunochemical characterization of ventricular CSF from Parkinson’s disease (PD) patients with adrenal medulla transplants in the patients. Neurology 1988; 38 (Suppl 1): 144.Google Scholar
11.Garnett, ES, Firnau, G, Chan, PKH, et al.[18F]–fluorodopa, an analog of dopa, and its use in direct external measurements of storage, degeneration, and turnover of intracerebral dopamine. Proc Natl Acad Sci USA 1978; 75: 137–138.CrossRefGoogle Scholar
12.Garnett, ES, Nahmias, C, Firnau, G. Central dopaminergic pathways in hemiparkinsonism examined by Positron Emission Tomography. Can J Neurol Sci 1984; 11: 174–179.CrossRefGoogle ScholarPubMed
13.Martin, WRW, Stoessl, AJ, Adam, MF, et al. Positron Emission Tomography in Parkinson’s Disease: Glucose and Dopa Metabolism. Adv Neurol 1986; 45: 95–98.Google Scholar
14.Leenders, KL, Palmer, AJ, Quinn, N, et al. Brain dopamine metabolism in patients with Parkinson’s disease measured with PET. J Neurol Neurosurg Psychiatry 1986; 49: 855–860.CrossRefGoogle Scholar
15.Yahr, MD, Duvoisin, RC, Schear, MJ, Barrett, RE, Hoehn, MM. Treatment of parkinsonism with levodopa. Arch Neurol 1969: 21: 343–354.CrossRefGoogle ScholarPubMed
16.Evans, B, Harrop, R, Heywood, D, et al. Engineering Developments on the UBC-TRIUMF Modified PETT VI Positron Emission Tomograph. IEEE Trans Nucl Sci 1982; NS-;30: 707–710.Google Scholar
17.Adam, MJ, Jivan, S. Synthesis and purification of L-6-[l8F] fluorodopa. J Appl Radiat Isotop (in press).Google Scholar
18.Firnau, G, Sood, S, Chirakal, R, et al. Cerebral Metabolism of 6[l8F] Fluoro-L-3, 4-Dihydroxyphenylalanine in the Primate. J Neurochem 1987; 48: 1077–1082.CrossRefGoogle ScholarPubMed
19.Hardebo, JE, Owman, C. Barrier mechanisms for neurotransmitter monoamines and their precursors at the blood-brain interface. Ann Neurol 1980; 8: 1–11.CrossRefGoogle ScholarPubMed
20.Martin, WRW, Cumming, P, Growchowski, E, et al. Regional Inhomogeneity of Blood–Brain Barrier Transport Systems. J Cereb Blood Flow Metab 1987; 7 (Suppl 1): S332.Google Scholar
21.Cumming, P, Hausser, M, Martin, WRW, et al. Kinetics of in vitro decarboxylation and the in vivo metabolism of 2-;l8F- and 6-l8-fluorodopa in the hooded rat. Biochem Pharm 1988; 37: 247–250.CrossRefGoogle Scholar
22.Garnett, ES, Firnau, G, Nahmias, C, et al. Striatal dopamine metabolism in living monkeys examined by positron emission tomography. Brain Res 1983; 280: 169–171.CrossRefGoogle ScholarPubMed
23.Garnett, ES, Firnau, G, Nahmias, C. Dopamine visualized in the basal ganglia of living man. Nature 1983; 305: 137–138.CrossRefGoogle ScholarPubMed
24.Kessler, RM, Goble, JC, Bird, JH, et al.Measurement of blood-brain barrier permeability with positron emission tomography and [68Ga] EDTA. J Cereb Blood Flow Metab 1984; 4: 3233–328.CrossRefGoogle ScholarPubMed
25.Ericson, K, Bergstrom, M, Eriksson, L, et al. Positron emission tomography with 68Ga-EDTA compared with transmission computed tomography in the evaluation of brain infarcts. Acta Radiologica 1981; 22: 385–398.CrossRefGoogle ScholarPubMed
26.Rosenstein, JM. Adrenal medulla grafts produce blood-brain barrier dysfunction. Brain Res 1987; 414: 192–196.CrossRefGoogle ScholarPubMed
27.Rosenstein, JM, Brightman, MW. Alterations of the blood-brain barrier after transplantation of autonomic ganglia into the mammalian central nervous system. J Comp Neurol1 1986; 250: 339–351.CrossRefGoogle ScholarPubMed
28.Rosenstein, JM. Neocortical transplants in the mammalian brain lack a blood-brain barrier to macromolecules. Science 1987; 235: 772–774.CrossRefGoogle Scholar