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Pharmacological Modification of Blood-Brain Barrier Permeability Following a Cold Lesion

Published online by Cambridge University Press:  18 September 2015

Jennifer J. Raymond ,
David M. Robertson ,
Henry B. Dinsdale  and
Sukriti Nag
Jennifer J. Raymond*
Affiliation:
the Departments of Pathology and Medicine, Queen’s University and Kingston General Hospital. Kingston, Ontario
David M. Robertson
Affiliation:
the Departments of Pathology and Medicine, Queen’s University and Kingston General Hospital. Kingston, Ontario
Henry B. Dinsdale
Affiliation:
the Departments of Pathology and Medicine, Queen’s University and Kingston General Hospital. Kingston, Ontario
Sukriti Nag
Affiliation:
the Departments of Pathology and Medicine, Queen’s University and Kingston General Hospital. Kingston, Ontario
*
Queen’s University, Department of Pathology, Richardson Laboratory, Kingston, Ontario, Canada K7L 3N6
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Abstract

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The effect of desipramine, imidazole, thioridazine and trifluoperazine on blood-brain barrier(BBB) permeability after a 24 hour cold lesion was studied in rats. Changes in BBB permeability were determined using a quantitative horseradish peroxidase (HRP) assay. The four drugs tested did not alter the quantity of HRP in the cortex of control animals, or in the contralateral cortex of test animals. However, imidazole, desipramine and trifluoperazine significantly reduced the HRP extravasation in and around the cold lesion. Several mechanisms for this effect are suggested; one possible mechanism common to all these drugs is the reduction of increased vesicular transport in cortical vessels adjacent to the cold lesions.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 11 , Issue 4 , November 1984 , pp. 447 - 451
Copyright
Copyright © Canadian Neurological Sciences Federation 1984

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