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Positron Emission Tomography in Parkinson’s Disease

Published online by Cambridge University Press:  18 September 2015

Barry J. Snow
Barry J. Snow*
Affiliation:
Division of Neurology, Department of Medicine, University Hospital, Vancouver
*
Division of Neurology, Department of Medicine, University Hospital – U.B.C. Site, 2211 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 1W5
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Abstract:

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Positron emission tomography (PET) allows the study of physiological and neurochemical processes which would otherwise be inaccessible, using radioactive labels on biological compounds to follow their fate in the body. By analysing changes of concentration with time we can measure blood flow, neuronal metabolism and receptor ligand interactions. In Parkinson’s disease (PD), PET has been used to examine the dopaminergic deficit and its relationship to motor performance. It has also been shown to detect asymptomatic dopaminergic lesions that have implications for the etiology of PD. In untreated PD there is increased density of D2 binding sites, while in chronically treated PD with motor fluctuations, D2 receptor density is reduced. [18F]-fluorodeoxyglucose studies of demented PD patients show a pattern of cortical metabolism similar to Alzheimer’s disease. Activation studies, which measure changes in blood flow during the performance of motor tasks, show reduced activation of medial frontal areas in PD.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 19 , Issue S1: 3rd Canadian Conference on Neurodegenerative Diseases , February 1992 , pp. 138 - 141
Copyright
Copyright © Canadian Neurological Sciences Federation 1992

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