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Postural Instability and Cognitive Dysfunction in Early Parkinson's Disease

Published online by Cambridge University Press:  02 December 2014

Jong Moon Lee ,
Seong-Beom Koh ,
Sung Won Chae ,
Woo-Keun Seo ,
Do Young Kwon ,
Ji Hyun Kim ,
Kyungmi Oh ,
Jong Sam Baik  and
Kun Woo Park
Jong Moon Lee
Affiliation:
Department of Neurology, Korea University College of Medicine
Seong-Beom Koh*
Affiliation:
Department of Neurology, Korea University College of Medicine
Sung Won Chae
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Korea University College of Medicine
Woo-Keun Seo
Affiliation:
Department of Neurology, Korea University College of Medicine
Do Young Kwon
Affiliation:
Department of Neurology, Korea University College of Medicine
Ji Hyun Kim
Affiliation:
Department of Neurology, Korea University College of Medicine
Kyungmi Oh
Affiliation:
Department of Neurology, Korea University College of Medicine
Jong Sam Baik
Affiliation:
Department of Neurology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea
Kun Woo Park
Affiliation:
Department of Neurology, Korea University College of Medicine
*
Department of Neurology, Korea University College of Medicine Guro Hospital, #80 Guro-Dong, Guro-Ku, Seoul, Korea 152-703. e-mail: parkinson@korea.ac.kr
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Abstract

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Background:

Postural instability is one of the most disabling features of Parkinson's disease, usually occurring in late and advanced stages. The aim of this study was to investigate the postural performance of early-stage de novo Parkinson's disease patients with no clinical postural instability using computerized dynamic posturography. We sought to understand the relationship between postural sway and disease severity and the relationship between postural instability quantitatively measured by computerized dynamic posturography and cognitive impairment in early-stage Parkinson's disease patients.

Method:

Thirty-one subjects with Parkinson's disease and 20 healthy controls were assessed by the computerized dynamic posturography protocol using the sensory organization test and the motor control test. A neuropsychological assessment was also administered.

Results:

The mean equilibrium score for sensory organization test and the vestibular input ratio were significantly correlated with Hoehn-Yahr stage. No associations between motor latency for any motor control test condition and Hoehn-Yahr stage were found. The equilibrium score for sensory organization test correlated with the mini-mental status examination scores. There was a significant correlation between motor latency for large backward translation and mini-mental status examination scores. There were significant correlations between visual perception/construction/ memory of the neuropsychological battery test and the equilibrium score for sensory organization test and between verbal word learning test, controlled word association test and motor latency for large backward translation.

Conclusion:

These findings showed the postural instability present in early-stage (Hoehn-Yahr stage 2-2.5) Parkinson's disease. We also found a close relationship between postural instability and cognitive function in Parkinson's disease patients.

Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 39 , Issue 4 , July 2012 , pp. 473 - 482
Copyright
Copyright © The Canadian Journal of Neurological 2012

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