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Progress in Clinical Neurosciences: Sepsis-Associated Encephalopathy: Evolving Concepts

Published online by Cambridge University Press:  16 December 2016

John X. Wilson  and
G. Bryan Young
John X. Wilson*
Affiliation:
Departments of Physiology, the University of Western Ontario, London, Ontario, Canada
G. Bryan Young
Affiliation:
Clinical Neurological Sciences, the University of Western Ontario, London, Ontario, Canada
*
Division of Neurology, Sunnybrook and Women's Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5
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Abstract:

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Systemic sepsis commonly produces brain dysfunction, sepsis-associated encephalopathy, which can vary from a transient, reversible encephalopathy to irreversible brain damage. The encephalopathy in the acute phase clinically resembles many metabolic encephalopathies: a diffuse disturbance in cerebral function with sparing of the brain stem. The severity of the encephalopathy, as reflected in progressive EEG abnormalities, often precedes then parallels dysfunction in other organs. Recent research has revealed a number of potentially important, non-mutually exclusive, mechanisms that have therapeutic implications.

Résumé:

RÉSUMÉ:

La septicémie induit communément une dysfonction cérébrale, l'encéphalopathie associée à la septicémie, dont la sévérité varie d'une encéphalopathie transitoire réversible au dommage cérébral irréversible. En phase aiguë, l'encéphalopathie ressemble cliniquement à plusieurs autres encéphalopathies métaboliques: une perturbation diffuse de la fonction cérébrale épargnant le tronc cérébral. L'encéphalopathie, comme en témoigne les anomalies progressives observées à l'ÉEG, précède souvent la dysfonction des autres organes puis évolue parallèlement à cette dysfonction. Des recherches récentes ont révélé plusieurs mécanismes potentiellement importants, qui ne sont pas mutuellement exclusifs et qui ont des implications thérapeutiques.

Type
Review Article
Information
Canadian Journal of Neurological Sciences , Volume 30 , Issue 2 , May 2003 , pp. 98 - 105
Copyright
Copyright © The Canadian Journal of Neurological 2003

References

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