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Progress in Clinical Neurosciences: The ‘Antiplatelet’ Agents and the Role of the Endothelium

Published online by Cambridge University Press:  02 December 2014

Farrah J. Mateen  and
Ashfaq Shuaib
Farrah J. Mateen
Affiliation:
The College of Medicine, University of Saskatchewan, Saskatoon, SK
Ashfaq Shuaib
Affiliation:
Division of Neurology, University of Alberta, Edmonton, AB, Canada
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Abstract

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The antiplatelet drugs, commonly used in the prevention and treatment of cerebrovascular disease, possess a number of effects that are independent of direct antiplatelet actions. Beneficial and detrimental effects both occur. The endothelium is an important mediator of these non-antiplatelet effects. We performed a literature search to locate articles related to acetylsalicylic acid (aspirin), clopidogrel, ticlopidine, and dipyridamole and the interactions of these medications with the endothelium. The role of each of the above medications is explored in relation to vasodilation, inflammation, oxidation, platelet-leukocyte interactions, and thrombogenic tendency via platelet-vessel wall interactions.

Résumé:

RÉSUMÉ:

Agents antiplaquettaires et rôle de l'endothélium. Les antiplaquettaires utilisés couramment dans la prévention et le traitement de la maladie cérébrovasculaire ont certains effets qui sont indépendants de l'activité antiplaquettaire directe. Certains sont bénéfiques, d'autres sont néfastes. L'endothélium est un médiateur important de ces effets non antiplaquettaires. Nous avons fouillé la littérature pour trouver des articles sur l'acide acétylsalicylique, le clopidogrel, la ticlopidine et le dipyridamole et leurs interactions avec l'endothélium. Nous examinons le rôle de chacun de ces médicaments dans la vasodilatation, l'inflammation, l'oxydation, les interactions plaquettes-leucocytes et la thrombogénicité via les interactions plaquettes-paroi vasculaire.

Type
Review Article
Information
Canadian Journal of Neurological Sciences , Volume 34 , Issue 3 , August 2007 , pp. 270 - 279
Copyright
Copyright © The Canadian Journal of Neurological 2007

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