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Recent Progress: Supersensitivity of Central Neurons — A Brief Review of an Emerging Concept

Published online by Cambridge University Press:  18 September 2015

G.G. Yarbrough  and
J.W. Phillis
G.G. Yarbrough
Affiliation:
Department of Physiology, University of Saskatchewan, Saskatoon, Canada
J.W. Phillis*
Affiliation:
Department of Physiology, University of Saskatchewan, Saskatoon, Canada
*
Department of Physiology, University of Saskatchewan, Saskatoon, Canada S7N 0W0
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The concept that “denervation” or “pharmacological disuse” supersensitivity develops in central neuronal systems subsequent to sustained attenuation of normal neurohumoral mechanisms is reviewed. Particular emphasis is placed on biochemical and electrophysiological parameters of supersensitivity in dopaminergic (striatal) neuronal systems. The possible applicability of theories invoking changes in receptor sensitivity to the phenomenon of narcotic tolerance and physical dependence and to psychoactive drug therapy is discussed.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 2 , Issue 3 , August 1975 , pp. 147 - 152
Copyright
Copyright © Canadian Neurological Sciences Federation 1975

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