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Rupture of an Experimentally Induced Aneurysm in a Primate

Published online by Cambridge University Press:  18 September 2015

F. Espinosa ,
B. Weir  and
T. Noseworthy
F. Espinosa
Affiliation:
Division of Neurosurgery and the Department of Medicine, Faculty of Medicine, The University of Alberta
B. Weir
Affiliation:
Division of Neurosurgery and the Department of Medicine, Faculty of Medicine, The University of Alberta
T. Noseworthy
Affiliation:
Division of Neurosurgery and the Department of Medicine, Faculty of Medicine, The University of Alberta
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Summary

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Cerebral aneurysms are extremely rare in all animals except man. We report the occurrence of a carotid-ophthalmic aneurysm in a cynomolgous monkey two months following accidental occlusion of the ipsilateral cervical internal carotid artery. This was documented angiographically. The aneurysm was deliberately ruptured by the insertion and withdrawal of fine needles. This produced a large subarachnoid hemorrhage visualized on CT scan. There was a progressive severe fall in cerebral blood flow and moderate vasospasm. The neurological status deteriorated on the tenth day and the animal was sacrificed on day 13. On electron microscopy, the aneurysm showed a fibrous wall, and the endothelium showed balloon-like endothelial cells with gaps. Corrugations occurred in the inner aspect of the anterior circulation arteries.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 11 , Issue 1 , February 1984 , pp. 64 - 68
Copyright
Copyright © Canadian Neurological Sciences Federation 1984

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