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A Spontaneous Recurrent Seizure Bioassay for Anti-Epileptogenic Molecules

Published online by Cambridge University Press:  02 December 2014

Angela P. Lyon ,
Dan Wainman ,
Sandra Marone  and
Donald F. Weaver
Angela P. Lyon
Affiliation:
Department of Chemistry, Queen’s University, Kingston, Ontario, Canada
Dan Wainman
Affiliation:
Department of Chemistry, Queen’s University, Kingston, Ontario, Canada
Sandra Marone
Affiliation:
Department of Chemistry, Queen’s University, Kingston, Ontario, Canada
Donald F. Weaver
Affiliation:
Departments of Chemistry and Medicine (Neurology), School of Biomedical Engineering, Dalhousie University, Halifax, Nova Scotia, Canada
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Abstract

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Drug design in epilepsy is now tackling a new target - epileptogenesis. This is the process whereby a normal brain becomes susceptible to recurrent seizures. One of the stumbling blocks in the design and discovery of new chemical entities as antiepileptogenics is the implementation of an appropriate biological model. Current models, such as the maximal electroshock model, are models of seizures, not models of epileptogenesis. To develop such a model, we have extended and modified a chronic pilocarpine spontaneous recurrent seizure (SRS) model for the purposes of developing a bioassay with which to screen new compounds for putative antiepileptogenic bioactivity.

La conception de médicaments antiépileptiques s’attaque maintenant à une nouvelle cible -l’épileptogenèse, le processus par lequel un cerveau normal devient sujet à des crises àpileptiques ràcurrentes. Une des pierres d’achoppement dans la conception et la dàcouverte de nouveaux produits chimiques antiàpileptogènes est la mise au point d’un modèle biologique approprià. Les modèles actuels comme le modèle d’àlectrochoc maximal sont des modèles de crises àpileptiques et non pas des modèles d’àpileptogenèse. Afin de dàvelopper un tel modèle, nous avons àlargi et modifià un modèle de crises convulsives ràcurrentes spontanàes en ràponse à l’administration de pilocarpine dans le but de dàvelopper un bioessai pour àvaluer l’actività antiàpileptogène de nouveaux composàs.

Type
Experimental Neurosciences
Information
Canadian Journal of Neurological Sciences , Volume 32 , Issue 1 , February 2005 , pp. 97 - 102
Copyright
Copyright © The Canadian Journal of Neurological 2014

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