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Structural Abnormalities are Similar in Familial and Nonfamilial Mesial Temporal Lobe Epilepsy

Published online by Cambridge University Press:  02 December 2014

Fabio Thadeu Ferreira ,
Eliane Kobayashi ,
Iscia Lopes-Cendes  and
Fernando Cendes
Fabio Thadeu Ferreira
Affiliation:
Department of Neurology, Faculdade de Ciências Médicas, Campinas State University, Campinas, São Paulo, Brazil
Eliane Kobayashi
Affiliation:
Department of Neurology, Faculdade de Ciências Médicas, Campinas State University, Campinas, São Paulo, Brazil
Iscia Lopes-Cendes
Affiliation:
Department of Medical Genetics, Faculdade de Ciências Médicas, Campinas State University, Campinas, São Paulo, Brazil
Fernando Cendes
Affiliation:
Department of Neurology, Faculdade de Ciências Médicas, Campinas State University, Campinas, São Paulo, Brazil
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Abstract

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Background/Objective:

Diffuse temporal lobe abnormalities can be observed on MRI of patients with mesial temporal lobe epilepsy (MTLE). Our objective was to perform qualitative and quantitative analyses of temporal lobe structures in patients with familial MTLE (FMTLE) and nonfamilial MTLE.

Methods:

Two groups of patients were ascertained: 67 FMTLE patients (14 with refractory seizures) and 30 patients with nonfamilial refractory MTLE. We performed qualitative analyses of MRI (with multiplanar reconstruction) and volumes of hippocampi and anterior temporal lobes in all patients, and in a normal control group of 23 individuals. We used the Chi-square test and ANOVA for statistical analyses.

Results:

We identified anterior temporal lobe abnormalities by visual analysis in only 4% of FMTLE patients and atrophy of the anterior temporal lobe by volumetric analysis in 19%. In the group of nonfamilial MTLE patients we found anterior temporal lobe abnormalities by visual analysis in 17% of patients and anterior temporal lobe atrophy in 13%. Hippocampal atrophy was present in 90% of FMTLE and in 83% of nonfamilial MTLE. No signs of cortical dysplasia were observed.

Conclusion:

Anterior temporal lobe atrophy and other abnormalities outside the mesial portion of temporal lobes were infrequent in both familial and nonfamilial MTLE patients. Despite the genetic basis, hippocampal atrophy in FMTLE is not associated with other abnormalities outside the mesial temporal regions.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 31 , Issue 3 , August 2004 , pp. 368 - 372
Copyright
Copyright © The Canadian Journal of Neurological 2004

References

1.Berkovic, SF, McIntosh, A, Howell, RA, et al.Familial temporal lobe epilepsy - a common disorder identified in twins. Ann Neurol 1996;40:227–235.CrossRefGoogle ScholarPubMed
2.Cendes, F, Lopes-Cendes, I, Andermann, E, Andermann, F.Familial temporal lobe epilepsy: a clinically heterogeneous syndrome. Neurology 1998;50(2): 554–557.Google Scholar
3.Kobayashi, E, Sousa, SC, Lopes-Cendes, I, et al.Seizure outcome and hippocampal atrophy in familial mesial temporal lobe epilepsy. Neurology 2001;56(2):166–172.Google Scholar
4.Kobayashi, E, D’Agostino, MD, Lopes-Cendes, I, et al.Hippocampal atrophy and T2 weighted signal changes in familial mesial temporal lobe epilepsy. Neurology 2003; 60(3):405–409.CrossRefGoogle ScholarPubMed
5.Kobayashi, E, Li, LM, Lopes-Cendes, I, Cendes, F.Magnetic resonance imaging evidence of hippocampal sclerosis in asymptomatic, first-degree relatives of patients with familial mesial temporal lobe epilepsy. Arch Neurol 2002; 59:1891–1894.Google Scholar
6.Cendes, F, Andermann, F, Gloor, P, et al.MRI volumetric measurement of amygdala and hippocampus in temporal lobe epilepsy. Neurology 1993;43:719–725.Google Scholar
7.Jack, CR, Sharbrough, FW, Twomey, CK, et al.Temporal lobe seizures: lateralization with magnetic resonance volume measurements of the hippocampal formation. Radiology 1990;175:423–429.Google Scholar
8.Lencz, T, McCarthy, G, Bronen, RA, et al.Quantitative magnetic resonance imaging in temporal lobe epilepsy: relationship to neuropathology and neuropsychological function. Ann Neurol 1992;31:627–629.Google Scholar
9.Lee, JW, Reutens, DC, Dubeau, F, et al.Morphometry in temporal lobe epilepsy. Magn Reson Imaging 1995;13:1073–1080.Google Scholar
10.Marsh, L, Morrel, ML, Shear, PK, et al.Cortical and hippocampal deficits in temporal lobe epilepsy. Epilepsia 1997; 38:576–587.Google Scholar
11.Briellmann, RS, Jackson, GD, Kalnins, R, et al.Hemicranial volume deficits in patients with temporal lobe epilepsy with and without hippocampal sclerosis. Epilepsia 1998;39(11):1174–1181.Google Scholar
12.Watson, C, Andermann, F, Gloor, P, et al.Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging. Neurology 1992;42:1743–1750.CrossRefGoogle ScholarPubMed
13.Robertson, SJ, Wolpert, SM, Runge, VM.MR imaging of middle cranial fossa arachnoid cysts: temporal lobe agenesis syndrome revisited. AJNR Am J Neuroradiol 1989;10(5):1007–1010.Google Scholar
14.Kuzniecky, R, Garcia, JH, Faught, E, Morawetz, RB.Cortical dysplasia in temporal lobe epilepsy: magnetic resonance imaging correlations. Ann Neurol 1991;29:293–298.Google Scholar
15.Ho, SS, Kuzniecky, R, Gilliam, F, et al.Temporal lobe developmental malformations and epilepsy: dual pathology and bilateral hippocampal abnormalities. Neurology 1998; 50(3): 748–754.Google Scholar
16.Kobayashi, E, D´Agostino, MD, Lopes-Cendes, I, et al.Outcome of surgical treatment in familial mesial temporal lobe epilepsy. Epilepsia 2003; 44(8): 1080–1084.Google Scholar
17.Breier, JI, Leonard, CM, Bauer, RM, et al.Quantified volumes of temporal lobe structures in patients with epilepsy. J Neuroimaging 1996;6:108–114.Google Scholar
18.Ottman, R, Risch, N, Hauser, WA, et al.Localization of a gene for partial epilepsy to chromosome 10q. Nat Genet 1995;10(1):56–60.Google Scholar
19.Poza, JJ, Sáenz, A, Martinez-Gil, A, et al.Autosomal dominant lateral temporal epilepsy: clinical and genetic study of a large Basque pedigree linked to chromosome 10q. Ann Neurol 1999;45:182–188.Google Scholar
20.Winawer, MR, Boneschi, FM, Barker-Cummings, C, et al.Four new families with autosomal dominant partial epilepsy with auditory features: clinical description and linkage to chromosome 10q24. Epilepsia 2002;43(1):60–67.Google Scholar
21.Singh, R, Scheffer, IE, Crossland, K, Berkovic, SF.Generalized epilepsy with febrile seizures plus: a common childhood-onset genetic epilepsy syndrome. Ann Neurol 1999;45(1):75–81.Google Scholar
22.Scheffer, IE, Phillips, HA, O’Brien, CE, et al.Familial partial epilepsy with variable foci: a new partial epilepsy syndrome with suggestion of linkage to chromosome 2. Ann Neurol 1998;44(6):890–899.Google Scholar
23.Hauser, WA.The natural history of temporal lobe epilepsy. In: Lüders, HO (Ed). Epilepsy Surgery. New York: Raven Press, 1992:133–141.Google Scholar
24.Gloor, P.Mesial temporal sclerosis: historical background and an overview from a modern perspective. In: Lüders, H, (Ed). Epilepsy surgery. New York: Raven Press, 1991: 689–703.Google Scholar
25.Jackson, GD, Berkovic, SF, Tress, BM, et al.Hippocampal sclerosis can be reliably detected by magnetic resonance imaging. Neurology 1990;40:1869–1875.Google Scholar
26.Berkovic, SF, Andermann, F, Olivier, A, et al.Hippocampal sclerosis in temporal lobe epilepsy demonstrated by magnetic resonance imaging. Ann Neurol 1991;29:175–182.Google Scholar
27.Watson, C, Jack, CR, Cendes, F.Volumetric magnetic resonance imaging: clinical applications and contributions to the understanding of temporal lobe epilepsy. Arch Neurology 1997; 54: 1521–1531.CrossRefGoogle Scholar